35 Results for "

natriuretic peptide receptor

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "natriuretic peptide receptor" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P1237
CAS No.: 127869-51-6
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P1237A
CAS No.: 1966153-17-2
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P72303
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPR2; Atrial natriuretic peptide B-Type receptor; Prev. ANPRB; Atrionatriuretic peptide receptor B; Prev. AMDM; natriuretic peptide receptor B; Prev. NPRB; Guanylate Cyclase; GC-B; ANPR-B; Atrial natriuretic peptide receptor Type B; GUC2B; Atrial Natriure
Species:  
Human
Source:  
P. pastoris
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P703074
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPR1; ANPR-A; Prev. ANPRA; ANP-A; Prev. NPRA; GC-A; Guanylate Cyclase A; natriuretic peptide receptor A/Guanylate Cyclase A (Atrionatriuretic peptide receptor A); GUCY2A; natriuretic peptide A Type receptor; ANPa; Testicular Tissue Protein Li 20; Atrial N
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P0003
CAS No.: 124584-08-3
Synonyms: Brain natriuretic peptide-32 human; BNP-32
Nesiritide (Brain Natriuretic Peptide-32 human) is a recombinant human B-type natriuretic peptide. Nesiritide is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide shows vasodilatory, diuretic, and natriuretic activities. Nesiritide is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .
loading...
    loading...
Cat. No.: HY-P3503
CAS No.: 1480724-61-5
Synonyms: BMN 111
Target:  

FGFR

Research Areas:  

Others

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .
loading...
    loading...
Cat. No.: HY-P3503A
Synonyms: BMN 111 acetate
Target:  

FGFR

Research Areas:  

Others

Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .
loading...
    loading...
Cat. No.: HY-P1419
CAS No.: 124833-45-0
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .
loading...
    loading...
Cat. No.: HY-Y0265
CAS No.: 91-56-5
Synonyms: Indoline-2,3-dione
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .
loading...
    loading...
Cat. No.: HY-P990951
CAS No.: 2845128-05-2
Synonyms: REGN-5381
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .
loading...
    loading...
Cat. No.: HY-P2026
CAS No.: 132956-87-7
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [ 125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .
loading...
    loading...
Cat. No.: HY-P3624
CAS No.: 507289-11-4
Target:  

Guanylate Cyclase

Research Areas:  

Cardiovascular Disease

Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
loading...
    loading...
Cat. No.: HY-149453
CAS No.: 2747162-85-0
Purity:  99.85%
Target:  

Guanylate Cyclase

Research Areas:  

Cardiovascular Disease

MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy .
loading...
    loading...
Cat. No.: HY-143316
CAS No.: 2768328-61-4
Purity:  99.30%
Target:  

Guanylate Cyclase

Research Areas:  

Neurological Disease

NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties .
loading...
    loading...
Cat. No.: HY-P10278
CAS No.: 133658-45-4
Target:  

Inhibitory Antibodies

Research Areas:  

Endocrinology

Anantin binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine adrenal cortex (Kd = 0.6 μM) and acts as natriuretic peptide receptor A antagonist .
loading...
    loading...
Cat. No.: HY-P2687
CAS No.: 118812-69-4
Synonyms: Urodilatin (human)
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure .
loading...
    loading...
Cat. No.: HY-P1401
CAS No.: 113731-96-7
Target:  

PKC

Research Areas:  

Metabolic Disease

Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response .
loading...
    loading...
Cat. No.: HY-P1980
Target:  

Apoptosis

Research Areas:  

Metabolic Disease

A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells .
loading...
    loading...
Cat. No.: HY-P0003A
CAS No.: 1684439-46-0
Synonyms: Brain natriuretic peptide-32 human acetate; BNP-32 acetate
Nesiritide (Brain Natriuretic Peptide-32 human) acetate is a recombinant human B-type natriuretic peptide. Nesiritide acetate is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide acetate shows vasodilatory, diuretic, and natriuretic activities. Nesiritide acetate is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .
loading...
    loading...
Cat. No.: HY-P3562
CAS No.: 952295-80-6
Target:  

Inhibitory Antibodies

Research Areas:  

Others

PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC50 value of 42.7 nM .
loading...
    loading...