2. Peptides
  3. Ularitide

Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.

For research use only. We do not sell to patients.

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Ularitide Chemical Structure

Ularitide Chemical Structure

CAS No. : 118812-69-4

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Ularitide Related Antibodies

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Description

Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].

In Vitro

Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells[2].
Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi[3].
Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ularitide Related Antibodies
In Vivo

Ularitide (10 nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female dogs with or without surgically induced chronic aortocaval fistula[1]
Dosage: 5 and 10 pmol/kg/min
Administration: i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min.
Result: Increased in urine volume and sodium excretion with high-output CHF.
Clinical Trial
Molecular Weight

3505.96

Formula

C145H234N52O44S3
CAS No.
Sequence

Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge:Cys11-Cys27)
Sequence Shortening

TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge:Cys11-Cys27)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ularitide118812-69-4Urodilatin (human)OthersHeart failurenatriuretic peptidebovine bronchidopamine metabolismrenal receptorInhibitorinhibitorinhibit

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