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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
nephron
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "nephron" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-B0632
CAS No.: 42399-41-7
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
11
11 Publications Verification
Synonyms: CRD-401
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Synonyms: CRD-401-d3
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d3 hydrochloride (CRD-401-d3) is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Synonyms: MG-13054
Target:
Research Areas:
Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension .
Cat. No.: HY-B0632S
CAS No.: 1242184-41-3
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d6 is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-174668
Target:
Research Areas:
Human HNF1B mRNA encodes the human HNF1 homeobox B (HNF1B) protein, a member of the homeodomain-containing superfamily of transcription factors. HNF1B has been shown to function in nephron development, and regulates development of the embryonic pancreas.
Cat. No.: HY-106300
CAS No.: 107804-48-8
Target:
Research Areas:
AA 193 is an orally active uricosuric agent. AA 193 inhibits the net reabsorption of uric acid in nephrons, regulates the renal reabsorption process of filtered uric acid, promotes uric acid excretion in a dose-dependent manner, and reduces serum uric acid levels. AA 193 mildly inhibits the activity of xanthine dehydrogenase (XDH). AA 193 can be used in studies related to hyperuricemia .
Cat. No.: HY-B0632A
CAS No.: 144604-00-2
Synonyms: MK 793
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem (MK 793) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-B0632S2
CAS No.: 112259-41-3
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d4 is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-B0632R
CAS No.: 42399-41-7
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem (Standard) is the analytical standard of Diltiazem (HY-B0632). This product is intended for research and analytical applications. Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-14656R
CAS No.: 33286-22-5
Synonyms: CRD-401 (Standard)
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem hydrochloride (Standard) (CRD-401 (Standard)) is the analytical standard of Diltiazem hydrochloride (HY-14656). This product is intended for research and analytical applications. Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-14656S2
CAS No.: 1309283-34-8
Synonyms: CRD-401-d6
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d6 hydrochloride (CRD-401-d6) is the deuterated-labeled Diltiazem hydrochloride (HY-14656). Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-14656S3
CAS No.: 2012598-70-6
Synonyms: CRD-401-d5
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d5 hydrochloride (CRD-401-d5) is the deuterated-labeled Diltiazem hydrochloride (HY-14656). Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-14656S1
CAS No.: 1217860-13-3
Synonyms: CRD-401-(acetoxy-d3)
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-(acetoxy-d3) hydrochloride (CRD-401-(acetoxy-d3)) is the deuterated-labeled Diltiazem hydrochloride (HY-14656). Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
Cat. No.: HY-126179R
CAS No.: 20287-37-0
Synonyms: MG-13054 (Standard)
Target:
Research Areas:
Fenquizone (MG-13054) (Standard) is the analytical standard of Fenquizone (HY-126179). This product is intended for research and analytical applications. Fenquizone is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension.
Cat. No.: HY-14656S4
CAS No.: 2699608-24-5
Synonyms: CRD-401-d4-1
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem-d4-1 hydrochloride (CRD-401-d4-1) is the deuterated-labeled Diltiazem hydrochloride (HY-14656). Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
