127 Results for "

prohormone convertase 5

" in MedChemExpress (MCE) Product Catalog:
Products (127)

127 Results for "prohormone convertase 5" in MCE Product Catalog:

  • Targets Recommended:
22
22 Publications Verification
Cat. No.: HY-P80622
Synonyms: CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-F, IHC-P, ELISA

Reactivity:  

Human, Mouse

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14
14 Cited Publications
Cat. No.: HY-32351
CAS No.: 19356-17-3
Synonyms: 25-Hydroxy Vitamin D3
Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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14
14 Cited Publications
Cat. No.: HY-32351A
CAS No.: 63283-36-3
Synonyms: 25-hydroxy Vitamin D3 monohydrate
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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7
7 Cited Publications
Cat. No.: HY-P1028
CAS No.: 673202-67-0
Synonyms: Furin Inhibitor II
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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7
7 Cited Publications
Cat. No.: HY-120088A
CAS No.: 1632250-50-0
Purity:  99.44%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34 .
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7
7 Cited Publications
Cat. No.: HY-120088
CAS No.: 1632250-49-7
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .
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7
7 Cited Publications
Cat. No.: HY-P1028A
CAS No.: 958204-56-3
Synonyms: Furin Inhibitor II TFA
Target:  

Bacterial

Research Areas:  

Infection

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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7
7 Cited Publications
Cat. No.: HY-P81232
Synonyms: caspase-1 isoform alpha subunit; CASP1; ICE; IL1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

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5
5 Cited Publications
Cat. No.: HY-12402
CAS No.: 489415-96-5
Purity:  99.28%
Target:  

PCSK9

Research Areas:  

Cardiovascular Disease

SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism .
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5
5 Cited Publications
Cat. No.: HY-P80587
Synonyms: CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45

Host:  

Rabbit

Application:  

WB, IHC-P, ELISA

Reactivity:  

Human, Mouse, Rat

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3
3 Cited Publications
Cat. No.: HY-113252
CAS No.: 362-08-3
Purity:  96.25%
2-Methoxyestrone is an estrogen metabolite with antimitotic activity. 2-Methoxyestrone acts as a liver-specific prohormone that undergoes demethylation to form active 2-hydroxyestrogens, and it can also interconvert with 2-Methoxyestradiol (HY-12033) via the 17β-hydroxysteroid dehydrogenase pathway. In the presence of all-trans retinoic acid, 2-Methoxyestrone exerts a strong, concentration-dependent inhibitory effect on cell growth. 2-Methoxyestrone delays the progression of pulmonary hypertension in rats, alleviates right ventricular and pulmonary vascular remodeling, and relieves proliferative pulmonary hypertension in rats. 2-Methoxyestrone can be used in studies related to proliferative pulmonary hypertension .
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2
2 Cited Publications
Cat. No.: HY-W010696
CAS No.: 5817-39-0
Synonyms: 3′,5′,3-Triiodothyronine
Research Areas:  

Cardiovascular Disease

Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine . Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes .
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2
2 Cited Publications
Cat. No.: HY-P78747
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FURIN; Subtilisin-Like Proprotein convertase 1; Prev. PCSK3; Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein); Prev. PACE; Furin (Paired Basic Amino Acid Cleaving Enzyme); Prev. FUR; Proprotein convertase Subtilisin/Ke
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P72117
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CASP1; Caspase 1, Apoptosis-Related Cysteine Peptidase (Interleukin 1, Beta, convertase); Prev. IL1BC; CDNA FLJ59442, Highly Similar To Caspase-1; Caspase-1; CDNA FLJ58540, Highly Similar To Caspase-1; ICE; Interleukin 1-B Converting Enzyme; P45; CASP1 Ni
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-101832
CAS No.: 1629166-02-4
Purity:  99.55%
Target:  

PCSK9

SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1 .
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1
1 Cited Publications
Cat. No.: HY-128342
CAS No.: 2365402-67-9
Purity:  99.14%
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
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1
1 Cited Publications
Cat. No.: HY-P2237
CAS No.: 65147-09-3
Research Areas:  

Endocrinology

Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays .
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1
1 Cited Publications
Cat. No.: HY-P73340
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated convertase 1; FH3; LDLCQ1; Proprotein convertase 9; FHCL3; NARC1; Propro
Species:  
Rat
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73728
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated convertase 1; FH3; LDLCQ1; Proprotein convertase 9; FHCL3; NARC1; Propro
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P71189A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCSK9; PC9; Prev. HCHOLA3; Hypercholesterolemia, Autosomal Dominant 3; NARC-1; Neural Apoptosis Regulated convertase 1; Subtilisin/Kexin-Like Protease PC9; Neural Apoptosis-Regulated convertase 1; FH3; LDLCQ1; Proprotein convertase 9; FHCL3; NARC1; Propro
Species:  
Mouse
Source:  
HEK293
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