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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
recombinant CYP3A4
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "recombinant CYP3A4" in MCE Product Catalog:
Cat. No.: HY-19958
CAS No.: 912656-34-9
Target:
Research Areas:
XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain .
Cat. No.: HY-113482
CAS No.: 80434-32-8
Synonyms: 1β-OH-DCA
Target:
Synonyms: 16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA
Target:
Research Areas:
16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.
Cat. No.: HY-125505
CAS No.: 1622159-00-5
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Research Areas:
BI-11634 is an orally active factor Xa inhibitor and a CYP3A4 substrate. The apparent Km values for BI-11634 metabolism are 23 μM in human liver microsomes (HLMs) and 7.6 μM with recombinant CYP3A4. BI-11634 can be used for thromboembolic disease and CYP3A4-mediated drug metabolism research .
Cat. No.: HY-10672
CAS No.: 1034708-07-0
Research Areas:
Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM) .
Cat. No.: HY-125505A
CAS No.: 864295-20-5
Research Areas:
BI-11634 free base is an orally active factor Xa inhibitor and a CYP3A4 substrate. The apparent Km values for BI-11634 free base metabolism are 23 μM in human liver microsomes (HLMs) and 7.6 μM with recombinant CYP3A4. BI-11634 free base can be used for thromboembolic disease and CYP3A4-mediated drug metabolism research .
Cat. No.: HY-E72102
Target:
Research Areas:
Human CYP3A4, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 3A4, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP3A4 is a human cytochrome P450 subtype belonging to the CYP3 family, as well as a major metabolic enzyme. It is predominantly expressed in human liver and intestine, metabolizes a variety of active compounds, and activates multiple procarcinogens .
Cat. No.: HY-N21740
CAS No.: 219793-20-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
