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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
sperm membrane
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "sperm membrane" in MCE Product Catalog:
3
Target:
Research Areas:
Eosin Y (Acid Red 87 free base) is a soluble acid red dye molecule. Eosin Y has a wide application in organic synthesis as a photoredox catalyst. Eosin Y can be used as a component of Eosin-Nigrosin Sperm Viability Staining Solution (HY-DY2022) to assess sperm viability and identify the integrity of the membrane structure and function of inactive sperm .
3
Target:
Research Areas:
Eosin Y disodium (Acid Red 87) is a soluble acid red dye molecule. Eosin Y disodium has a wide application in organic synthesis as a photoredox catalyst. Eosin Y disodium can be used as a component of Eosin-Nigrosin Sperm Viability Staining Solution (HY-DY2022) to assess sperm viability and identify the integrity of the membrane structure and function of inactive sperm .
Synonyms: sn-1,2-Dioleoylglycerol; 18:1/18:1-DG
Cat. No.: HY-P10817
Research Areas:
Cat. No.: HY-NP180
Cat. No.: HY-P10817A
Research Areas:
Cat. No.: HY-W250145
CAS No.: 8005-03-6
Synonyms: Nigrosine
Target:
Research Areas:
Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin. Acid Black 2 can be used as a component of Eosin-Nigrosin Sperm Viability Staining Solution (HY-DY2022) to assess sperm viability and identify the integrity of the membrane structure and function of inactive sperm .
Synonyms: R-40244
Target:
Environmental Pollutants Apoptosis Bcl-2 Family Herbicide HSP PERK Eukaryotic Initiation Factor (eIF) Akt GSK-3 Reactive Oxygen Species (ROS)
Research Areas:
Flurochloridone (R-40244) is an orally active herbicide and an inducer of ER stress, apoptosis, and cytotoxicity. Flurochloridone upregulates GRP78 and activates the PERK-eIF2α-ATF4 UPR axis, ATF6, CHOP, Bax, and Bim. Flurochloridone decreases Akt, p-Akt, GSK3β, and p-GSK3β levels, and induces ROS, oxidative stress, γ-glutamyl cycle activation, and GSH accumulation. Flurochloridone inhibits mitochondrial respiration and ATP production while enhancing glycolysis and cell viability inhibition. Flurochloridone inhibits spermatogonial proliferation, spermatocyte meiosis, and sperm mitochondrial membrane potential, and induces Sertoli cell apoptosis and mitochondrial damage. Flurochloridone non-competitively binds phytoene desaturase, blocking phytoene desaturation and carotenoid synthesis, leading to leaf bleaching and phytotoxicity. Flurochloridone can be used for research on male reproductive toxicity, hepatotoxicity, and as a herbicide .
Research Areas:
MitoPBN is a AMPK/SIRT3/PGC-1α axis modulator, reactive oxygen species scavenger and mitochondrial function enhancer. MitoPBN increases the phosphorylation level of AMPK, restores SIRT3 expression and reverses the down-regulation of PGC-1α, thereby promoting mitochondrial biogenesis. MitoPBN regulates glucose metabolism, reduces blood glucose by inhibiting hepatic gluconeogenesis and increasing hepatic glucose uptake, while scavenging mitochondrial superoxide anion/hydrogen peroxide, maintaining membrane potential and increasing ATP production. MitoPBN also reduces cell apoptosis, improves sperm motility, survival rate and membrane integrity, but may induce reductive stress in cryopreserved sperm at high concentrations. MitoPBN is widely applicable to research related to diabetes and type 2 diabetes .
Cat. No.: HY-W338792
CAS No.: 22248-63-1
Synonyms: 1-Decanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine
Target:
Research Areas:
1-Decanoyl-sn-glycero-3-phosphocholine (1-Decanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine) is a lipidic compound that can be found in sperm membrane lipids .
Cat. No.: HY-135438
CAS No.: 22550-76-1
Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity .
Cat. No.: HY-126476
CAS No.: 79162-16-6
Target:
Cat. No.: HY-DY2022
Target:
Research Areas:
Eosin-Nigrosin Sperm Viability Staining Solution is a differential viability staining solution used to distinguish live/dead sperm and other cells, consisting of Eosin Y (HY-D0505) and Nigrosin (HY-W250145). Eosin-Nigrosin Sperm Viability Staining Solution cannot penetrate the membrane of live cells; it stains dead cells dark pink and uses nigrosin to form a contrasting dark background. Eosin-Nigrosin Sperm Viability Staining Solution can distinguish live sperm, dead sperm and sperm with neck leakage, and can stain dead sperm or sperm affected by excessive microbial growth .
Cat. No.: HY-121337R
CAS No.: 61213-25-0
Synonyms: R-40244 (Standard)
Target:
Reference Standards Environmental Pollutants Apoptosis Bcl-2 Family Herbicide HSP PERK Eukaryotic Initiation Factor (eIF) Akt GSK-3 Reactive Oxygen Species (ROS)
Research Areas:
Flurochloridone (Standard) (R-40244 (Standard)) is the analytical standard of Flurochloridone (HY-121337). This product is intended for research and analytical applications. Flurochloridone (R-40244) is an orally active herbicide and an inducer of ER stress, apoptosis, and cytotoxicity. Flurochloridone upregulates GRP78 and activates the PERK-eIF2α-ATF4 UPR axis, ATF6, CHOP, Bax, and Bim. Flurochloridone decreases Akt, p-Akt, GSK3β, and p-GSK3β levels, and induces ROS, oxidative stress, γ-glutamyl cycle activation, and GSH accumulation. Flurochloridone inhibits mitochondrial respiration and ATP production while enhancing glycolysis and cell viability inhibition. Flurochloridone inhibits spermatogonial proliferation, spermatocyte meiosis, and sperm mitochondrial membrane potential, and induces Sertoli cell apoptosis and mitochondrial damage. Flurochloridone non-competitively binds phytoene desaturase, blocking phytoene desaturation and carotenoid synthesis, leading to leaf bleaching and phytotoxicity. Flurochloridone can be used for research on male reproductive toxicity, hepatotoxicity, and as a herbicide .
Cat. No.: HY-D3148
CAS No.: 1804107-88-7
Target:
Research Areas:
TPE-Ph-In is a mitochondria-targeted voltage-sensitive probe that can be used for mitochondrial membrane potential detection, mitochondrial imaging of animal and plant cells and tissues, mouse sperm activity indication, and detection of mitochondrial membrane potential changes associated with early apoptosis. TPE-Ph-In is non-fluorescent in solution, but emits strong fluorescence when aggregated via restriction of intramolecular rotation/movement, and its fluorescence intensity is directly correlated with local probe concentration or mitochondrial membrane potential level. TPE-Ph-In can penetrate cell membranes, target mitochondria through charge-dependent accumulation, has low cytotoxicity and high photostability, and enables super-resolution imaging of plant mitochondrial fission, fusion and cristae structures. The excitation wavelengths of TPE-Ph-In include 450 nm, 488 nm, and 489 nm, while its emission wavelengths include 551-661 nm, 660 nm, and 694 nm. TPE-Ph-In can be used for studies on mitochondrial dysfunction associated with early apoptosis .
Cat. No.: HY-P77080
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MCEMP1; Mast Cell-Expressed membrane Protein 1; Prev. C19orf59; Mast Cell-Expressed membrane Protein 1, Isoform CRA_a; Epididymis Secretory sperm Binding Protein; Chromosome 19 Open Reading Frame 59; Mast Cell Expressed membrane Protein 1; MGC132456
Species:
Human
Source:
HEK293
Cat. No.: HY-P77747
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MCEMP1; Mast Cell-Expressed membrane Protein 1; Prev. C19orf59; Mast Cell-Expressed membrane Protein 1, Isoform CRA_a; Epididymis Secretory sperm Binding Protein; Chromosome 19 Open Reading Frame 59; Mast Cell Expressed membrane Protein 1; MGC132456
Species:
Mouse
Source:
HEK293
Cat. No.: HY-182832
Synonyms: Dry skim milk; Non-fat milk solids; Skimmed milk powder
Cat. No.: HY-P70938
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITM2B; ImBRI2; Integral membrane Protein 2B; Epididymis Secretory sperm Binding Protein; BRI2; Integral membrane Protein 2; BRI; ABri/ADan Amyloid Peptide; BRICD2B; Protein E25B; E3-16; RDGCA; E25B; ABRI; BRICHOS Domain Containing 2B; FBD; Transmembrane P
Species:
Human
Source:
HEK293
Cat. No.: HY-P704108
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DPEP3; membrane-Bound Dipeptidase 3; Dipeptidase 3; Dipeptidase 3, Isoform CRA_c; Testis Secretory sperm-Binding Protein Li 211a; MBD3; Metallopeptidase (Family M19)
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
