8 Results for "

steric stabilization

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "steric stabilization" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-140740
Purity:  99.48%
Target:  

Liposome

Research Areas:  

Others

DSPE-PEG5000-Maleimide, is a linker lipid containing DSPE phospholipid and Maleimide. DSPE-PEG-Maleimide is used in the synthesis of liposomes, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes .
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1
1 Cited Publications
Cat. No.: HY-W039897
CAS No.: 617-04-9
Synonyms: α-Methyl-D-mannoside
Target:  

Bacterial

Research Areas:  

Infection

Methyl α-D-mannopyranoside (α-Methyl-D-mannoside) is a methyl glycoside derivative and conformational stabilizer of α-D-mannopyranose. The glycosidic bond conformation of Methyl α-D-mannopyranoside is significantly affected by the environment. In aqueous solution, Methyl α-D-mannopyranoside stabilizes into a trans conformation via intermolecular hydrogen bonds; in the gas phase, however, steric interactions drive Methyl α-D-mannopyranoside to prefer a clockwise gauche conformation. Methyl α-D-mannopyranoside also serves as a major component of secondary cell wall polymers in some bacteria and an active precursor site for virus-targeted glycoproteins. Methyl α-D-mannopyranoside acts as an acceptor substrate for alternansucrase, mediating the transfer of D-glucopyranosyl groups to generate a variety of glycosylated oligosaccharide products, with methyl α-D-glucopyranosyl-(1→6)-α-D-mannopyranoside as the main component. Methyl α-D-mannopyranoside is applicable to studies on bacterial pathogenic mechanisms associated with mannose-specific fimbrial lectins .
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Cat. No.: HY-155882
CAS No.: 80506-64-5
Synonyms: mPEG750-NH2
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
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Cat. No.: HY-W591476
CAS No.: 134874-49-0
Synonyms: mPEG1000-SH
m-PEG1000-thiol (mPEG1000-SH) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].
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Cat. No.: HY-W250183
CAS No.: 9005-00-9
Synonyms: Polyethylene glycol octadecyl ether (n~10, average Mn~711)
Research Areas:  

Others

Polyoxyethylene (10) stearyl ether (Polyethylene glycol octadecyl ether (n~10, average Mn~711)) is a nonionic surfactant. Polyoxyethylene (10) stearyl ether reduces interfacial tension through its amphiphilic structure, stabilizes emulsions via steric hindrance, and forms micelles for solubilization. Polyoxyethylene (10) stearyl ether can serve as a biomaterial or organic compound for life science-related research.
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Cat. No.: HY-123745
CAS No.: 439932-74-8
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Aβ aggregation-IN-6 is an Aβ aggregation inhibitor with ~60-70% inhibition of Aβ17-40 aggregation. Aβ aggregation-IN-6 stabilizes Aβ dimer assembly, binds to Aβ steric-zipper assembly. Aβ aggregation-IN-6 can be used for the research of alzheimer's disease .
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Cat. No.: HY-W800635
CAS No.: 2566404-74-6
Research Areas:  

Others

4-Azide-TFP-Amide-PEG4-acid contains an aryl azide and a carboxylic acid with a PEG spacer to increase aqueous solubility and decrease steric hinderance during ligation. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond.
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Cat. No.: HY-P11698
CAS No.: 476667-31-9
Research Areas:  

Cancer

Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .
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