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stimulator of interferon genes (STING)

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By Targets:	IFNAR (4) STING (32) Cyclic GMP-AMP Synthase (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (2) Influenza Virus (2) Reference Standards (1) Topoisomerase (1)
By Research Areas:	Cancer (25) Infection (3) Inflammation/Immunology (17) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

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Targets Recommended: STING IFNAR AIM2

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-10964

Vadimezan 70+ Cited Publications DMXAA; ASA-404	STING IFNAR Influenza Virus	Infection Cancer
Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the **stimulator of interferon genes** (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-112921A

diABZI STING agonist-1 45+ Cited Publications	STING	Inflammation/Immunology
diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively .

HY-12512

cGAMP 25+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-112921B

diABZI STING agonist-1 trihydrochloride 45+ Cited Publications	STING	Inflammation/Immunology Cancer
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-12885A

2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt Maximum Cited Publications 87 Publications Verification ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).

HY-12885

2’3’-c-di-AM(PS)2 (Rp,Rp) Maximum Cited Publications 87 Publications Verification ADU-S100; MIW815; ML RR-S2 CDA	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-12885B

2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Maximum Cited Publications 87 Publications Verification ADU-S100 ammonium salt; MIW815 ammonium salt; ML RR-S2 CDA ammonium salt	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-123943

STING agonist-4 5+ Cited Publications	STING	Cancer
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC₅₀) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .

HY-112921

diABZI STING agonist-1 (tautomerism) 2 Publications Verification	STING	Inflammation/Immunology
diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921A). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively .

HY-110385

cGAMP disodium 25+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

HY-139586

Ulevostinag MK-1454	STING	Cancer
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of **stimulator of interferon genes (STING)*. STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING* .

HY-176566

H-151 Alkyne	STING	Inflammation/Immunology
H-151 Alkyne (Compound H-151-AL) is a selective *STING* (Stimulator of interferon genes) inhibitor. H-151 Alkyne is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases .

HY-164288

TDI-6570 TDI-006570	Cyclic GMP-AMP Synthase STING	Neurological Disease Inflammation/Immunology
TDI-6570 (TDI-006570) is a blood-brain barrier-permeable, orally active cGAS inhibitor with an IC₅₀ of 1.64 μM. TDI-6570 exhibits high gastrointestinal absorption and a long brain half-life in mice, and shows no toxicity to primary neurons. By inhibiting the *cGAS-STING-IFN* signaling pathway, TDI-6570 reduces *STING* levels and the activation of TBK1, blocks double-stranded DNA-induced cGAS activation and downstream interferon-stimulated gene expression, thereby reducing tau protein spread and improving synaptic loss. TDI-6570 reverses memory deficits, increases the amplitude of long-term potentiation, enhances the MEF2C transcriptional network, restores PSD-95 and vGAT punctate structures, and significantly improves cognitive resilience. TDI-6570 can be applied to the research of Alzheimer's disease, Parkinson's disease, systemic lupus erythematosus, as well as various central nervous system and autoimmune diseases .

HY-131994

STING agonist-16 1 Publications Verification	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .

HY-12885C

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt	IFNAR	Inflammation/Immunology
2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING) .

HY-158615

STING18 stimulator of interferon genes 18	Others	Others
STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.

HY-162465

BDW568	STING IFNAR	Cancer
BDW568 is a selective *STING* ^A230 agonist with an EC₅₀ of 5.7 μM. BDW568 triggers the *interferon* signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research .

HY-148346

STING agonist-20-Ala-amide-PEG2-C2-NH2	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .

HY-141662

2',3'-cGAMP-C2-PPA	STING Drug-Linker Conjugates for ADC	Inflammation/Immunology Cancer
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases .

HY-151264

BSP16	STING	Cancer
BSP16 is a potent, orally active **stimulator of interferon genes (STING)** agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer .

HY-110385A

cGAMP diammonium 25+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

HY-152861

Dazostinag TAK-676 free base	STING	Cancer
Dazostinag (TAK-676 free base) is an agonist of **stimulator of interferon genes** (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs) .

HY-10964R

Vadimezan (Standard) DMXAA (Standard); ASA-404 (Standard)	STING IFNAR Influenza Virus Reference Standards	Infection Cancer
Vadimezan (Standard) (DMXAA (Standard)) is the analytical standard of Vadimezan (HY-10964). This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-130116

IACS-8779	STING	Cancer
IACS-8779 is a highly potent **stimulator of interferon genes (STING)** agonist with robust systemic antitumor efficacy .

HY-163749

STING-IN-8	STING	Inflammation/Immunology
STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC₅₀ value of 0.121 μM in human and an IC₅₀ value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated *STING* signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of *STING*-associated inflammatory and autoimmune diseases .

HY-155100

BI 7446	STING	Inflammation/Immunology Cancer
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .

HY-148346A

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .

HY-175462

INI3069	STING	Cancer
INI3069 is a selective human stimulator of interferon gene (STING) agonist. INI3069 is promising for research of cancers .

HY-153987

STING agonist-33	STING	Cancer
STING agonist-33 (example 1) is an agonist of STING (stimulator of interferon genes) based on 4-ethyl-2-methylthiazole-5-carboxylic acid ^{[1] ^.}

HY-139586C

Ulevostinag (isomer 3) MK-1454 (isomer 3)	STING	Cancer
Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research .

HY-130116A

IACS-8779 disodium	STING	Cancer
IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma .

HY-151513

Iso5-2DC18	Others	Cancer
Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity .

HY-155109

Antitumor agent-114	STING	Inflammation/Immunology Cancer
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research .

HY-182926

Topoisomerase I/II-IN-9	DNA/RNA Synthesis Topoisomerase	Cancer
Topoisomerase I/II-IN-9 is a topoisomerase I/II inhibitor (IC₅₀<10 μM) and a DNA damage inducer. Topoisomerase I/II-IN-9 blocks the interaction between the enzyme and DNA by binding to the DNA-binding pocket of the enzyme. Topoisomerase I/II-IN-9 activates the *cGAS-STING* pathway and promotes the accumulation of cytoplasmic double-stranded DNA. This further drives the production of type I interferons, CCL5, CXCL10 and interferon-stimulated genes, and induces anti-tumor immune responses in vivo. Topoisomerase I/II-IN-9 can be applied to the research of related diseases such as triple-negative breast cancer, colorectal cancer and gastric cancer .

cGAMP disodium 25+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

cGAMP diammonium 25+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natürliche Produkte Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates a signaling cascade leading to the production of type I interferons* and other immune mediators .

Species:	Human (3) Mouse (1)
Tag:	SUMO (2) His (4)
Source:	E. coli Cell-free (1) P. pastoris (1) E. coli (2)

Art. -Nr.	Compare	Produktname	Species	Source	Image

HY-P70700

	Sting1/TMEM173 Protein, Human (Sumo-His) 2 Publications Verification stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. Sting1/TMEM173 Protein, Human (Sumo-His) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P70700A

	Sting1/TMEM173 Protein, Human (N-His-Sumo) 3 Publications Verification stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	E. coli
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. Sting1/TMEM173 Protein, Human (N-His-Sumo) is the recombinant human-derived TMEM173 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P706005

	Sting1/TMEM173 Protein, Human (P. pastoris, His) stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;	Human	P. pastoris
	The TMEM173 protein acts as a promoter of innate immune signaling, acting as a sensor of bacterial and viral cytoplasmic DNA, ultimately promoting the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to the delivery of non-CpG double-stranded DNA from viruses and bacteria into the cytoplasm. Sting1/TMEM173 Protein, Human (P. pastoris, His) is the recombinant human-derived TMEM173 protein, expressed by P. pastoris , with C-6*His labeled tag.

HY-P705449

	Sting1/TMEM173 Protein, Mouse (Cell-Free, His) Sting1; Eris; Mita; Mpys; Tmem173; stimulator of interferon genes protein; mSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; MMITA; Transmembrane protein 173	Mouse	E. coli Cell-free
	STING is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS and DAMPS. Sting1/TMEM173 Protein, Mouse (Cell-Free, His) is the recombinant Sting1/TMEM173 protein, expressed by E. coli, with N-10*His labelled tag.

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HY-P86617

	STING Antibody (YA6309) TMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; stimulator of interferon genes protein; hSTING	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STING Antibody (YA6309) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STING.

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Art. -Nr.	Produktname		Classification

HY-176566

H-151 Alkyne		Alkynes
H-151 Alkyne (Compound H-151-AL) is a selective *STING* (Stimulator of interferon genes) inhibitor. H-151 Alkyne is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases .

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stimulator of interferon genes (STING)

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