2138299-33-7
2138299-33-7
Chemical Structure
diABZI STING agonist-1
- CAS No.: 2138299-33-7
- Formula:C42H51N13O7
- Molecular Weight:849.94
SMILES: O=C(N)C1=CC(N=C(NC(C2=CC(C)=NN2CC)=O)N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)=C3C(OC)=C1
Biological Activity: diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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diABZI STING agonist-1 | 99.58% | diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. | ||||||||||||||||||||
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diABZI STING agonist-1 (Standard) | ≥98% | diABZI STING agonist-1 (Standard) is the analytical standard of diABZI STING agonist-1 (HY-112921A). This product is intended for research and analytical applications. diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. | ||||||||||||||||||||
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diABZI STING agonist-1 trihydrochloride | 99.84% | diABZI STING agonist-1 trihydrochloride is a selective stimulator of interferon genes (STING) receptor agonist. | ||||||||||||||||||||
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STING agonist-17 | 96.15% | STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization. | ||||||||||||||||||||
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STING agonist-18 | 99.84% | STING agonist-18 (compound 1a) is a STING agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate. | ||||||||||||||||||||
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STING agonist-19 | STING agonist-19 can be used to synthesize ISAC (immune-stimulating antibody conjugates) molecule. | |||||||||||||||||||||
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STING agonist-22 | 99.83% | STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research. | ||||||||||||||||||||
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STING agonist-31 | STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency. | |||||||||||||||||||||
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diABZI-4 | 98.33% | diABZI-4 is a STING activator and broad-spectrum antiviral agent with immunostimulatory activity. diABZI-4 triggers the TBK1-IRF3 and NF-κB signaling cascades by inducing STING oligomerization, thereby promoting the production of type I/III interferons and various proinflammatory cytokines. diABZI-4 exhibits broad-spectrum antiviral activity and effectively inhibits the replication of influenza A virus, SARS-CoV-2, herpes simplex virus, and other viruses. diABZI-4 also activates lymphocytes and macrophages to provide significant pre- and post-exposure protection in viral disease models. diABZI-4 can be used to study COVID-19, respiratory viral infections, and related immunopathological mechanisms. | ||||||||||||||||||||
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STING agonist-49 | STING agonist-49 (Compound 1) is a STING agonist and can be used as a payload for ADCs. STING agonist-49 can be applied in lung cancer research. | |||||||||||||||||||||
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STING ligand-5 | STING ligand-5 (Compound 4) is a ligand for target protein of PROTAC, which is applicable to the synthesis of PROTAC UNC9036 (HY-158048). | |||||||||||||||||||||
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STING agonist-51 | STING agonist-51 (example 3) is a bis-benzimidazole STING agonist. STING agonist-51 can be used for the research of cancer. | |||||||||||||||||||||
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