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Cat. No.: HY-152955

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STING agonist-22

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.83%
CAS No.: 2408723-12-4
화학식: C₄₀H₄₈N₁₄O₆
분자량:820.90

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

STING agonist-22 Chemical Structure

CAS No.: 2408723-12-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

STING agonist-22 (CF501) leads to rapid and robust activation of innate immune responses in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STING agonist-22 (CF501) robustly, but transiently, activates innate immunity with acceptable safety profile in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c mice (female, six weeks old)^[1]
Dosage:

20, 75 μg
Administration:

Intramuscular injection
Result:

Although innate immunity was activated only transiently by CF501, it should be sufficient to stimulate the required humoral and cellular immune responses. The half-life of CF501 was 0.5 h and there was no detectable CF501 in the plasma after 2 h of the injection.

Chemical Information

CAS No. 2408723-12-4
Appearance Solid
분자량 820.90
화학식 C₄₀H₄₈N₁₄O₆
Color White to off-white
SMILES

NC(C1=CC2=C(N=C1)N(C/C=C/CN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=C3C(OCCCN6CCOCC6)=CC(C(N)=O)=C5)C(NC(C7=CC(C)=NN7CC)=O)=N2)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

NPJ Vaccines

Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies. [Abstract]

2026 Jan 28;11(1):55. PMID: 41605953
Res Sq

2025 Oct 12.

용액&용해도

In Vitro:

DMSO : 100 mg/mL (121.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2182 mL

6.0909 mL

12.1818 mL

5 mM

0.2436 mL

1.2182 mL

2.4364 mL

10 mM

0.1218 mL

0.6091 mL

1.2182 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2182 mL	6.0909 mL	12.1818 mL	30.4544 mL
	5 mM	0.2436 mL	1.2182 mL	2.4364 mL	6.0909 mL
	10 mM	0.1218 mL	0.6091 mL	1.2182 mL	3.0454 mL
	15 mM	0.0812 mL	0.4061 mL	0.8121 mL	2.0303 mL
	20 mM	0.0609 mL	0.3045 mL	0.6091 mL	1.5227 mL
	25 mM	0.0487 mL	0.2436 mL	0.4873 mL	1.2182 mL
	30 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0151 mL
	40 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7614 mL
	50 mM	0.0244 mL	0.1218 mL	0.2436 mL	0.6091 mL
	60 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL
	80 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.3807 mL
	100 mM	0.0122 mL	0.0609 mL	0.1218 mL	0.3045 mL

Keywords

STING agonist-22

2 Cited Publications

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References

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STING agonist-22

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Immunopotentiator Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) STING agonist-22

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

STING agonist-22

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Immunopotentiator Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) STING agonist-22

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

STING agonist-22 Related Classifications

HY-152955 Related Classifications