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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
surface pH
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "surface pH" in MCE Product Catalog:
4
4 Cited Publications
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Forschungsgebiete:
KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein .
Art. -Nr.: HY-W243303J
CAS. Nr.: 9003-01-4
Art. -Nr.: HY-D0075
CAS. Nr.: 61255-63-8
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Carboxymethyl Dextran (CM-Dextran) is a dextran derivative and a biocompatible coating for superparamagnetic iron oxide nanoparticles. When coated on the surface of superparamagnetic nanoparticles, Carboxymethyl Dextran forms stable particles across all pH values and NaCl concentrations. Carboxymethyl Dextran can be used to prepare materials for magnetic resonance molecular imaging .
Art. -Nr.: HY-D1556
CAS. Nr.: 384832-91-1
Synonyms: 1,2-dioleoyl-sn-glycero-3-pHospHoethanolamine-N-(carboxyfluorescein) ammonium
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18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .
Art. -Nr.: HY-W129456
CAS. Nr.: 4214-72-6
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Isaxonine acts as a modifier of the surface pH of the bilayer . Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery . Isaxonine is a neurotrophic agent .
Art. -Nr.: HY-133847
CAS. Nr.: 61792-31-2
Synonyms: Laurylamidopropyldimethylamine oxide
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LAPAO (Laurylamidopropyldimethylamine oxide) is an amphoteric surfactant with good biocompatibility and surface activity. LAPAO can be used as a detergent and foam enhancer for personal care and household cleaning products. LAPAO is stable at different pH values and can effectively remove dirt and grease. LAPAO also has a conditioning effect and is suitable for use in skin care and hair care products .
Art. -Nr.: HY-W739372
CAS. Nr.: 25704-18-1
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Poly (sodium 4-styrenesulfonate) is an anionic cation-exchange polyelectrolyte and metal ion binding/retention agent. It selectively retains Cr III and Fe II under pH 1 conditions, and its retention effect on all tested metal ions is enhanced under higher pH conditions. Poly (sodium 4-styrenesulfonate) inhibits nanosheet aggregation through edge-face interactions between aromatic rings and the graphite surface, thereby stabilizing the dispersion of reduced graphene oxide nanosheets. When incorporated into the mixed Nafion coating of bismuth film electrodes, Poly (sodium 4-styrenesulfonate) improves the reproducibility, stability, sensitivity, and anti-fouling capability for trace metal detection .
Art. -Nr.: HY-124703
CAS. Nr.: 65004-42-4
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Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM .
Art. -Nr.: HY-E70311
Synonyms: Thermomyces lanuginosus lipase
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1,3-specific lipase,Bacillus lanolin (Immobilized)(Thermomyces lanuginosus lipase) is a high-efficiency biocatalyst, a lipase from Thermomyces lanuginosus. 1,3-specific lipase,Bacillus lanolin (Immobilized) can be conjugated to magnetic nanoparticles and coupled to the surface of Fe(3)O(4)-COOH to obtain better temperature resistance and pH resistance. The activity unit (U) of lipase is defined as the amount of enzyme that produces 1 μmol of fatty acid per minute under experimental conditions .
Art. -Nr.: HY-184638
APTS Fe2O3 Nanoparticles (Aminated ferric oxide magnetic nanoparticles) are magnetic nanomaterials modified with amino functional groups using APTS. This material consists of a ferric oxide (Fe3O4) nanoparticle core and an amino (-NH2) surface modification layer. The aminated surface helps improve the biocompatibility of the nanoparticles and reduce cytotoxicity. The amino functional groups can be further chemically modified for coupling with biomolecules such as drugs, proteins, and nucleic acids. The amino functional groups undergo protonation at different pH values, resulting in different surface charges on the nanoparticles in different pH environments.
Art. -Nr.: HY-184856
CAS. Nr.: 25232-41-1
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Poly(4-vinylpyridine) is a pyridine-functionalized polymer with pH responsiveness. Poly(4-vinylpyridine) is widely used in fields such as catalysis, water treatment and surface modification. Poly(4-vinylpyridine) serves as a pH-sensitive polymer shell in Au@p4VP core@shell nanocomposites, endowing them with biocompatibility .
Art. -Nr.: HY-P5423C
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Art. -Nr.: HY-184606
PEI stabilized gold nanoclusters (PEI-Au NCs) are nanomaterials combining gold nanoclusters and polyethyleneimine. They consist of a few to dozens of gold atoms forming the core of the gold nanoclusters, while polyethyleneimine (PEI), a positively charged hyperbranched polyamine, is selected as the end-capping agent, encapsulating the surface of the gold nanoclusters. PEI-Au NCs have gained widespread application due to their high luminescence properties and stability over a wide pH range. Furthermore, their good biocompatibility and ease of surface modification or functionalization make them attractive for many biomedical applications.
Art. -Nr.: HY-K3120
MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.
Art. -Nr.: HY-184603
Bovine serum albumin-modified gold nanoclusters (BSA-Au NCs) are nanomaterials combining gold nanoclusters and bovine serum albumin (BSA). Composed of several to dozens of gold atoms forming the core of the gold nanoclusters, BSA acts as a protective ligand, coating the surface of the gold nanoclusters. BSA-Au NCs are widely used due to their high luminescence properties and stability over a wide pH range. When Au(III) ions are introduced into a BSA solution, BSA acts as a scaffold protein, isolating and capturing Au ions, similar to the biomineralization behavior of inorganic ions in organisms in nature. The captured Au ions are then reduced in situ by BSA to form Au NCs. The synthesized Au NCs consist of 25-Au atoms and are stable in BSA as BSA-Au NCs, exhibiting strong red fluorescence. BSA-Au NCs possess good biocompatibility and their surface is easily modified or functionalized, making them attractive for many biomedical applications.
Art. -Nr.: HY-D3582
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AF633 C5 Maleimide is a fluorescent dye used for surface protein labeling of extracellular vesicles and peptide labeling. AF633 C5 Maleimide covalently binds to protein thiol residues under neutral pH conditions (6.5-7.5), enabling visualization and quantitative analysis of extracellular vesicle uptake by target cells. AF633 C5 Maleimide undergoes maleimide-cysteine conjugation with cysteine residues on peptides in acetonitrile-water buffer solution, supporting detection of peptide-functionalized gold nanorods via confocal laser scanning microscopy, as well as tracking their cellular uptake and localization .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
