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synthases

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1119

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3

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8

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18

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29

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1

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194

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78

Isotope-Labeled Compounds

8

Click Chemistry

14

Oligonucleotides

1

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103087
    FIN56
    20+ Cited Publications

    		 Ferroptosis Others
    FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .
    FIN56
  • HY-W142119
    α-Methyl-DL-aspartic acid
    4 Publications Verification

    		 Ser/Thr Protease Neurological Disease
    α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .
    α-Methyl-DL-aspartic acid
  • HY-133916
    G140
    5+ Cited Publications

    		 Cyclic GMP-AMP Synthase Inflammation/Immunology
    G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity .
    G140
  • HY-106392
    Lucerastat

    NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin

    		 Glucosylceramide Synthase (GCS) Metabolic Disease
    Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study .
    Lucerastat
  • HY-W011142
    2'-Deoxyuridine 5'-monophosphate disodium

    dUMP disodium

    		 Endogenous Metabolite Infection Metabolic Disease
    2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis .
    2'-Deoxyuridine 5'-monophosphate disodium
  • HY-117430
    Hymeglusin

    F-244; 1233A; L-659699

    		 Flavivirus Dengue Virus Antibiotic Infection Metabolic Disease Cancer
    Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys 129 residue of the enzyme .
    Hymeglusin
  • HY-100313A
    YM-53601
    5 Publications Verification

    		 Farnesyl Transferase HCV Infection Metabolic Disease
    YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
    YM-53601
  • HY-163689
    Vicadrostat

    BI 690517

    		 Mineralocorticoid Receptor Cardiovascular Disease Metabolic Disease
    Vicadrostat (BI 690517) is an orally active aldosterone synthase (aldosterone synthase) inhibitor, with IC50 values of 19 nM, 16 nM, and 18 μM against human, cynomolgus monkey, and rat aldosterone synthase, respectively. Vicadrostat has an in vivo IC50 of 25 nM for aldosterone synthesis. Vicadrostat exhibits high selectivity for cortisol synthase; it reduces aldosterone production and decreases plasma aldosterone levels. Vicadrostat can be used in the research of chronic kidney disease, heart failure, and hypertension .
    Vicadrostat
  • HY-147277
    Lorundrostat

    MT-4129

    		 Cytochrome P450 Cardiovascular Disease
    Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure .
    Lorundrostat
  • HY-W003969
    Aminopicoline

    Ascensil; 2-Amino-4-methylpyridine

    		 NO Synthase Inflammation/Immunology
    Aminopicoline (Ascensil) is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline competes with arginine at the substrate-binding site of nitric oxide synthase, reduces cellular nitric oxide production, inhibits the elevation of plasma nitrate, increases mean arterial pressure at high doses, and also serves as a basis for radiolabeled ligands to localize nitric oxide synthase binding sites. Aminopicoline can be used in the research of diseases associated with septic shock, joint inflammation, intestinal inflammation, and CNS inflammation .
    Aminopicoline
  • HY-147416
    Vipoglanstat

    BI 1029539; GS-248; OX-MPI

    		 PGE synthase Infection Cancer
    Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .
    Vipoglanstat
  • HY-158145
    DS55980254

    		Phospholipase Cancer
    DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway .
    DS55980254
  • HY-N8537
    Enfumafungin

    		Fungal Infection
    Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
    Enfumafungin
  • HY-102041
    SMS2-IN-1
    3 Publications Verification

    		 Phospholipase Inflammation/Immunology
    SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM) .
    SMS2-IN-1
  • HY-W356117
    C6 NBD Glucosylceramide

    		Fluorescent Dye Others
    C6 NBD Glucosylceramide is a glucosylceramide fluorescent derivative (Ex=466 nm, Em=535 nm). C6 NBD Glucosylceramide can be used to study the metabolism and internalization of glucosylceramide and also for the determination of glucosyl ceramide synthase activity .
    C6 NBD Glucosylceramide
  • HY-N9686
    Caffeoyl-CoA

    		Others Others Inflammation/Immunology
    Caffeoyl-CoA is a substrate of Chalcone synthase derived from rye with a Km value of 1.45 μM .
    Caffeoyl-CoA
  • HY-107923
    Sulfisoxazole acetyl

    N1-Acetylsulfisoxazole

    		 Bacterial Infection
    Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action .
    Sulfisoxazole acetyl
  • HY-W008821
    1,7-Heptanediamine

    		DNA/RNA Synthesis Others
    1,7-Heptanediamine (C7) is a deoxyhypusine synthase inhibitor with IC50 value of 4.5 μM .
    1,7-Heptanediamine
  • HY-144266
    TP-060

    Glucosylceramide synthase-IN-1

    		 Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .
    TP-060
  • HY-144267
    Glucosylceramide synthase-IN-2

    		Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .
    Glucosylceramide synthase-IN-2
  • HY-148433
    SpdSyn binder-1

    		Parasite Infection Inflammation/Immunology
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .
    SpdSyn binder-1
  • HY-151224
    Thermospermine

    		DNA/RNA Synthesis Others
    Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana .
    Thermospermine
  • HY-171160
    WYFA-15

    		SARS-CoV Infection
    WYFA-15 is a sphingomyelin synthase 1 (SMS1) inhibitor that protects mice against lethal SFTSV infection and reduce SARS-CoV-2 replication and pathogenesis. WYFA-15 can be utilized in anti-virus research .
    WYFA-15
  • HY-P2558
    GSK3 Substrate, α, β subunit

    		GSK-3 Others
    GSK3 Substrate, α, β subunit is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used to measure GSK-3 activity .
    GSK3 Substrate, α, β subunit
  • HY-B0865
    Pyrazosulfuron-ethyl
    1 Publications Verification

    		 Acetolactate Synthase (ALS) Others
    Pyrazosulfuron-ethyl, one of the acetolactate synthase inhibiting herbicides in the sulphonylurea family, has been widely used to control weed growth in commercial cereal, soybean, and vegetable fields .
    Pyrazosulfuron-ethyl
  • HY-12124
    BBS-4

    		NO Synthase Cardiovascular Disease
    BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis .
    BBS-4
  • HY-113752
    MMV019313

    		Parasite Infection
    MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC50 of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .
    MMV019313
  • HY-E70425
    Sucrose synthase

    		Glycosyltransferase Metabolic Disease
    Sucrose synthase belongs to glycosyltransferases and is a reversible catalyst present in plants, which catalyzes the conversion of sucrose into fructose and UDP-G or ADP-G. Sucrose synthase localizes to the cytoplasm, plasma membrane, cell wall, vacuole and mitochondria of plants. Sucrose synthase regulates sugar metabolism, supports the development of taproots, fruits, seeds and vascular tissues, drives the synthesis of starch, cellulose and callose, and enhances nitrogen fixation capacity. Sucrose synthase mediates signal transduction in plant meristems. Sucrose synthase is associated with plant growth, anaerobic stress tolerance, as well as shoot apical meristem and leaf morphology; overexpression of this enzyme promotes plant growth, increases xylem size, and elevates cellulose and starch contents .
    Sucrose synthase
  • HY-144270
    Glucosylceramide synthase-IN-3

    		Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research .
    Glucosylceramide synthase-IN-3
  • HY-146388
    Mtb ATP synthase-IN-1

    		Bacterial ATP Synthase Infection
    Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .
    Mtb ATP synthase-IN-1
  • HY-116535
    D-threo-PPMP hydrochloride

    		Glucosylceramide Synthase (GCS) Neurological Disease
    D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production .
    D-threo-PPMP hydrochloride
  • HY-D1577
    C6 NBD Lactosylceramide

    		Fluorescent Dye Cancer
    C6 NBD Lactosylceramide is a derivative of lactosylceramides, and can be used in lactosylceramide synthase assay as a fluorescent acceptor substrate. C6 NBD Lactosylceramide can also be used in cancer research .
    C6 NBD Lactosylceramide
  • HY-D1573
    C6 NBD Phytoceramide

    		Fluorescent Dye Others
    C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .
    C6 NBD Phytoceramide
  • HY-124781
    ML406

    		Bacterial Antibiotic Infection
    ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .
    ML406
  • HY-16110
    Tegafur-Uracil

    UFT; BMS-200604

    		 Thymidylate Synthase Cancer
    Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors .
    Tegafur-Uracil
  • HY-N11409A
    Shikimate-3-phosphate lithium

    		Herbicide Others
    Shikimate-3-phosphate lithium is the salt form of Shikimate-3-phosphate. Shikimate-3-phosphate lithium is a central microbial, parasite and plant metabolite, as a product of the shikimate kinase-catalysed reaction. Shikimate-3-phosphate lithium serves as an enzyme substrate for 5-enolpyruvoyl-shikimate 3-phosphate synthase, which is a target of anti-infectives and of herbicides .
    Shikimate-3-phosphate lithium
  • HY-130579
    Vinyl-L-NIO hydrochloride

    L-VNIO hydrochloride

    		 NO Synthase NADPH Oxidase Cardiovascular Disease Neurological Disease
    Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal nitric oxide synthase (NOS) inhibitor with a rat Ki of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits NADPH oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension .
    Vinyl-L-NIO hydrochloride
  • HY-178175
    Chitin synthase-IN-15

    		Insecticide Infection
    Chitin synthase-IN-15 (Compound 6k) is a chitin synthase inhibitor. Chitin synthase-IN-15 has insecticidal efficacy against Plutella xylostella, with LC50 values of 0.789 and 0.951 μg/mL. Chitin synthase-IN-15 induces molting disruptions, larval mortality, and aberrant pupation, thereby effectively mitigating pest populations. Chitin synthase-IN-15 is an insecticidal agent with favorable ecological safety profiles .
    Chitin synthase-IN-15
  • HY-139594
    Polyketide synthase 13-IN-1

    		Bacterial Infection Inflammation/Immunology
    Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor .
    Polyketide synthase 13-IN-1
  • HY-44688
    S.pombe lumazine synthase-IN-1

    		Bacterial Fungal Infection
    S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively .
    S.pombe lumazine synthase-IN-1
  • HY-150584
    Chitin synthase inhibitor 3

    		Fungal Infection
    Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .
    Chitin synthase inhibitor 3
  • HY-122060
    BYK 191023

    		NO Synthase Metabolic Disease
    BYK 191023 is a selective and L-arginine competitive inducible nitric-oxide synthase inhibitor with an IC50 value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .
    BYK 191023
  • HY-W585869
    Amorphadiene

    		Parasite Infection
    Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .
    Amorphadiene
  • HY-150583
    Chitin synthase inhibitor 2

    		Fungal Inflammation/Immunology
    Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
    Chitin synthase inhibitor 2
  • HY-105193
    E 3040

    		Lipoxygenase Prostaglandin Receptor Inflammation/Immunology
    E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect .
    E 3040
  • HY-116535C
    D-threo-PPMP

    		Glucosylceramide Synthase (GCS) Neurological Disease
    D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production .
    D-threo-PPMP
  • HY-W775186
    Tolprocarb

    		Fungal Infection
    Tolprocarb is an oomyces fungicide, which has a strong inhibitory effect on rice blast fungus Magnaporthe grisea by inhibiting polyketide synthase in melanin synthesis pathway .
    Tolprocarb
  • HY-W394006
    2'-Deoxyuridine 5'-monophosphate

    dUMP

    		 Endogenous Metabolite Infection Metabolic Disease
    2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis .
    2'-Deoxyuridine 5'-monophosphate
  • HY-125637
    Venturicidin B

    Aabomycin A2

    		 Antibiotic Fungal ATP Synthase Infection
    Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .
    Venturicidin B
  • HY-122016A
    BRD-4592

    		Bacterial Infection Inflammation/Immunology
    BRD-4592 is an allosteric inhibitor targeting Mycobacterium tuberculosis tryptophan synthase (TrpAB). BRD-4592 binds at the α-β-subunit interface of TrpAB, with an IC50 of 70.9 nM for the α-subunit and 22.6 nM for the β-subunit .
    BRD-4592

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