1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Selurampanel

Selurampanel (Synonyms: BGG 492)

Cat. No.: HY-105860
Handling Instructions

Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research.

For research use only. We do not sell to patients.

Selurampanel Chemical Structure

Selurampanel Chemical Structure

CAS No. : 912574-69-7

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Description

Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2].

In Vivo

Selurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment[1].
In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.42

Formula

C₁₆H₁₉N₅O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Selurampanel
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