Seriniquinone
Based on 1 Customer Validation
Seriniquinone, a selective anti-melanoma agent that targets Dermcidin, induces cell death by autophagocytosis. Seriniquinone is a metabolite produced by a rare marine bacterium of the genus Serinicoccus.
For research use only. We do not sell to patients.
- Purity: 98.39%
- CAS No.: 22200-69-7
- Formula: C20H8O4S
- Molecular Weight:344.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
2.38 μM
Compound: 11a
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Antiproliferative activity against mouse B16 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against mouse B16 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 36126897] |
| HCT-116 | IC50 |
1.29 μM
Compound: 1
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 30783501] |
| HL-60 | IC50 |
1.73 μM
Compound: 11a
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 36126897] |
| Malme-3M | IC50 |
0.05 μM
Compound: 1
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Cytotoxicity against human MALME-3M cells after 72 hrs by MTT assay
Cytotoxicity against human MALME-3M cells after 72 hrs by MTT assay
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[PMID: 30783501] |
| SK-MEL-28 | IC50 |
0.36 μM
Compound: 1
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Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
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[PMID: 30783501] |
Chemical Information
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CAS No. 22200-69-7
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Appearance Solid
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Molecular Weight 344.34
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Formula C20H8O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=C2C(C3=O)=C(C(C4=C3C=CC=C4)=O)S1)C5=C(C=CC=C5)C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (14.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Lynnie Trzoss, et al. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. [Content Brief]
[2]. Amanda S Hirata, et al. Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas. Molecules. 2021 Dec 4;26(23):7362. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9041 mL | 14.5205 mL | 29.0411 mL | 72.6027 mL |
| 5 mM | 0.5808 mL | 2.9041 mL | 5.8082 mL | 14.5205 mL | |
| 10 mM | 0.2904 mL | 1.4521 mL | 2.9041 mL | 7.2603 mL |
Seriniquinone Related Classifications
HY-120066 Related Classifications
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