2. PROTAC MAPK/ERK Pathway
  3. PROTACs p38 MAPK
  4. SJF-8240

SJF-8240 is a selective p38α PROTAC degrader. SJF-8240 promotes ubiquitination and selective degradation of p38α. SJF-8240 can be used in breast cancer-related research.
(Pink: c-Met/HGFR ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker (HY-W442078)).

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SJF-8240

SJF-8240 Chemische Struktur

CAS. Nr. : 2230821-68-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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SJF-8240 Related Antibodies

Top Publications Citing Use of Products

Alle PROTACs Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Alle p38 MAPK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • Biologische Aktivität

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Beschreibung

SJF-8240 is a selective p38α PROTAC degrader. SJF-8240 promotes ubiquitination and selective degradation of p38α. SJF-8240 can be used in breast cancer-related research[1][2]. (Pink: c-Met/HGFR ligand (HY-45124); Blue: VHL ligand (HY-125845); Black: linker (HY-W442078)).

IC50 & Target[1]

p38α

 

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
50 nM
Compound: Example 1
Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
Protac activity at E3 ubiquitin ligase/p38alpha in human MDA-MB-231 cells assessed as p38alpha degradation after 4 hrs by ELISA
[PMID: 30783495]
In Vitro

SJF-8240 selectively degrades p38α in MDA-MB-231 breast cancer cells, and its structural analog SJF-α exhibits potent p38α degradation activity (DC50 = 7.16 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJF-8240 Related Antibodies
Molekulargewicht

1106.24

Formel

C58H65F2N7O11S
CAS. Nr.
Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 100 mg/mL (90.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9040 mL 4.5198 mL 9.0396 mL
5 mM 0.1808 mL 0.9040 mL 1.8079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9040 mL 4.5198 mL 9.0396 mL 22.5991 mL
5 mM 0.1808 mL 0.9040 mL 1.8079 mL 4.5198 mL
10 mM 0.0904 mL 0.4520 mL 0.9040 mL 2.2599 mL
15 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5066 mL
20 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL
25 mM 0.0362 mL 0.1808 mL 0.3616 mL 0.9040 mL
30 mM 0.0301 mL 0.1507 mL 0.3013 mL 0.7533 mL
40 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
50 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4520 mL
60 mM 0.0151 mL 0.0753 mL 0.1507 mL 0.3767 mL
80 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2825 mL
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SJF-8240 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-82402230821-68-6SJF8240SJF 8240PROTACsp38 MAPKMAPK13MDA-MB-231 human breast cancer cellsVHL E3 ubiquitin ligasep38δbreast cancerMAPK14von Hippel-Lindauubiquitinationproteasomal degradationp38αInhibitorinhibitorinhibit

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