2. GPCR/G Protein MAPK/ERK Pathway
  3. SOS1 Ras
  4. SOS1-IN-15

SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer.

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SOS1-IN-15

SOS1-IN-15 화학구조

CAS No. : 2793404-47-2

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무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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SOS1-IN-15 Related Antibodies

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제품 설명

SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer[1].

IC50 & Target[1]

SOS1

5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MIA PaCa-2 IC50
178 nM
Compound: 8
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
[PMID: 37778239]
In Vitro

SOS1-IN-15 (Compound 37) (0.1 nM-0.1 mM; 72 h) displays prominent inhibitory activities in Mia-paca-2 cancer cells (IC50 = 178 ± 42 nM)[1].
SOS1-IN-15 has a limited inhibition of CYP and hERG[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOS1-IN-15 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Mia-paca-2 pancreas cancer cells
Concentration: 0.1 nM-0.1 mM
Incubation Time: 72 h
Result: Inhibited the proliferation with an IC50 of 178 ± 42 nM.
In Vivo

SOS1-IN-15 (Compound 37) (50 mg/kg; p.o.; daily for 22 days) inhibits tumor volume in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing Mia-paca-2 pancreas tumors[1]
Dosage: 50 mg/kg
Administration: Oral administration, daily for 22 days
Result: Showed 49% tumor inhibition. No animal mortality and significant difference in the mice’s body weight were observed during the study period.
Animal Model: Male CD-1 Mice[1]
Dosage: 20 mg/kg
Administration: Oral administration (Pharmacokinetic Analysis)
Result: In Vivo Pharmacokinetic Properties of the Compounds in Male CD-1 Micea
T1/2 (h) Tmax (h) Cmax (ng/mL) AUC (ng⋅h/mL) MRT (h) Kel (h-1)
SOS1-IN-15 11.4 3.67 1550 9900 4.19 0.25

aCompounds (20 mg/kg) were P.O. dosed in a mixture of 63% water + 30% PEG +5 % DMSO + 2% Tween 80 in male ICR mice (n = 3). Abbreviations: T1/2, elimination half-life; Tmax, plasma peak time after administration; Cmax, maximum plasma concentration; AUC, area under concentration-time curve. MRT, mean residence time; Kel, elimination rate constant.
분자량

536.55

화학식

C28H27F3N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1(CC1)C(N2CCN3C4=CC5=C(C=C4OC[C@H]3C2)N=C(C)N=C5N[C@H](C)C6=CC=CC(C(F)F)=C6F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMF : ≥ 100 mg/mL (186.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8638 mL 9.3188 mL 18.6376 mL
5 mM 0.3728 mL 1.8638 mL 3.7275 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.04%

SDS (251 KB)

COA (251 KB) HNMR (376 KB) LCMS (114 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.8638 mL 9.3188 mL 18.6376 mL 46.5940 mL
5 mM 0.3728 mL 1.8638 mL 3.7275 mL 9.3188 mL
10 mM 0.1864 mL 0.9319 mL 1.8638 mL 4.6594 mL
15 mM 0.1243 mL 0.6213 mL 1.2425 mL 3.1063 mL
20 mM 0.0932 mL 0.4659 mL 0.9319 mL 2.3297 mL
25 mM 0.0746 mL 0.3728 mL 0.7455 mL 1.8638 mL
30 mM 0.0621 mL 0.3106 mL 0.6213 mL 1.5531 mL
40 mM 0.0466 mL 0.2330 mL 0.4659 mL 1.1648 mL
50 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.9319 mL
60 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7766 mL
80 mM 0.0233 mL 0.1165 mL 0.2330 mL 0.5824 mL
100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.4659 mL
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SOS1-IN-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-152793404-47-2SOS1RasRas/Rac guanine nucleotide exchange factor 1orally activeKRAS-driven cancerMia-paca-2BALB/c nude miceInhibitorinhibitorinhibit

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상품명:
SOS1-IN-15
Cat. No.:
HY-151881
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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