2. Immunology/Inflammation
  3. STING Interleukin Related
  4. STING-IN-11

STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. STING-IN-11 can block the palmitoylation of the STING protein and STING downstream signaling, and inhibit STING-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of STING-related inflammatory and autoimmune diseases.

For research use only. We do not sell to patients.

STING-IN-11

STING-IN-11 Chemical Structure

CAS No. : 2925028-15-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

STING-IN-11 Related Antibodies

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View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. STING-IN-11 can block the palmitoylation of the STING protein and STING downstream signaling, and inhibit STING-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of STING-related inflammatory and autoimmune diseases[1].

Molecular Weight

403.85

Formula

C21H20ClF2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CNC2=C1C=C(Cl)C=C2)NC3=CC=C(C4CCC(F)(CC4)F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4762 mL 12.3808 mL 24.7617 mL
5 mM 0.4952 mL 2.4762 mL 4.9523 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4762 mL 12.3808 mL 24.7617 mL 61.9042 mL
5 mM 0.4952 mL 2.4762 mL 4.9523 mL 12.3808 mL
10 mM 0.2476 mL 1.2381 mL 2.4762 mL 6.1904 mL
15 mM 0.1651 mL 0.8254 mL 1.6508 mL 4.1269 mL
20 mM 0.1238 mL 0.6190 mL 1.2381 mL 3.0952 mL
25 mM 0.0990 mL 0.4952 mL 0.9905 mL 2.4762 mL
30 mM 0.0825 mL 0.4127 mL 0.8254 mL 2.0635 mL
40 mM 0.0619 mL 0.3095 mL 0.6190 mL 1.5476 mL
50 mM 0.0495 mL 0.2476 mL 0.4952 mL 1.2381 mL
60 mM 0.0413 mL 0.2063 mL 0.4127 mL 1.0317 mL
80 mM 0.0310 mL 0.1548 mL 0.3095 mL 0.7738 mL
100 mM 0.0248 mL 0.1238 mL 0.2476 mL 0.6190 mL
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STING-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-112925028-15-3STINGInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSILTHP1L929Toxicity ModelInflammatory ModelInhibitorinhibitorinhibit

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