Succinic anhydride

Name: Succinic anhydride
Brand: MedChemExpress
SKU: HY-79369
Rating: 4.5 (1 reviews)

Cat. No.: HY-79369 Pureté: ≥98.0%: FAQs
Fiche technique SDS COA Instruction de manipulation

Molarity Calculator

Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide.

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Succinic anhydride Chemical Structure

CAS No. : 108-30-5

Size	Prix	Stock	Quantité
Échantillon gratuit (0.1 - 0.5 mg)		Appliquer maintenant
25 g	USD 33	En stock	Estimated Time of Arrival: December 31
50 g	USD 50	En stock	Estimated Time of Arrival: December 31
> 100 g		Obtenir un devis

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Based on 1 publication(s) in Google Scholar

Other Forms of Succinic anhydride:

Succinic anhydride-d₄ Obtenir un devis
Succinic anhydride-¹³C₂ Obtenir un devis

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target^[1]

Non-cleavable Linker

Masse moléculaire

100.07

Formule

C₄H₄O₃

CAS No.

108-30-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(CC1)OC1=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (999.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.9930 mL	49.9650 mL	99.9300 mL
5 mM	1.9986 mL	9.9930 mL	19.9860 mL
10 mM	0.9993 mL	4.9965 mL	9.9930 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: ≥98.0%

Select Batch:

Fiche technique (272 KB) SDS (476 KB)

COA (248 KB) HNMR (112 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	9.9930 mL	49.9650 mL	99.9300 mL	249.8251 mL
	5 mM	1.9986 mL	9.9930 mL	19.9860 mL	49.9650 mL
	10 mM	0.9993 mL	4.9965 mL	9.9930 mL	24.9825 mL
	15 mM	0.6662 mL	3.3310 mL	6.6620 mL	16.6550 mL
	20 mM	0.4997 mL	2.4983 mL	4.9965 mL	12.4913 mL
	25 mM	0.3997 mL	1.9986 mL	3.9972 mL	9.9930 mL
	30 mM	0.3331 mL	1.6655 mL	3.3310 mL	8.3275 mL
	40 mM	0.2498 mL	1.2491 mL	2.4983 mL	6.2456 mL
	50 mM	0.1999 mL	0.9993 mL	1.9986 mL	4.9965 mL
	60 mM	0.1666 mL	0.8328 mL	1.6655 mL	4.1638 mL
	80 mM	0.1249 mL	0.6246 mL	1.2491 mL	3.1228 mL
	100 mM	0.0999 mL	0.4997 mL	0.9993 mL	2.4983 mL