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Cat. No.: HY-P11786

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SYN1327

SYN1327 is a monomeric peptide that selectively inhibits the hIgG-hFcRn interaction. SYN1327 binds to soluble human FcRn (shFcRn) with K_d values of 31 nM and 170 nM at pH 6 and 7.4, respectively.

For research use only. We do not sell to patients.

CAS No.: 1020264-43-0
Formula: C₇₂H₁₀₁N₁₉O₁₆S₂
Molecular Weight:1552.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYN1327 Chemical Structure

CAS No.: 1020264-43-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

SYN1327 shows equipotent binding to soluble human and cynomolgus monkey FcRn but ≈1,000-fold weaker binding to soluble mouse and rat FcRn at pH 6.0^[1].
SYN1327 shows only a weak nonspecific interaction between the peptides and a surface immobilized HLA-A2^[1].
SYN1327 (10 μM) does not inhibits the binding of shFcRn (1.2 μM) to a sensor chip coated with human serum albumin (HSA)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SYN1327 (10 mg/kg; i.v.) does not reduce hIgG concentration in transgenic mice (TG32B)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1020264-43-0
Molecular Weight 1552.82
Formula C₇₂H₁₀₁N₁₉O₁₆S₂
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)(SSC[C@@H](C(N)=O)NC2=O)C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC4=CC=CC=C4)C(NCC(N(C)CC(N(C)[C@@H](CC(C)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(N6[C@H]2CCC6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Sequence

Ac-Arg-Phe-Pen-Thr-Gly-His-Phe-Gly-Sar-{NMeLeu}-Tyr-Pro-Cys-NH2 (disulfide bridge:Pen3-Cys13)
Sequence Shortening

Ac-RF-Pen-TGHFG-Sar-{NMeLeu}-YPC-NH2 (disulfide bridge:Pen3-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mezo AR, et al. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2337-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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