T2 peptide-1
T2 peptide-1 is a linear peptide derived from Lumican degradation. T2 peptide-1 exhibits activity against endometrial adhesion progression and ability to inhibit the Lumican−Collagen I interaction. T2 peptide-1 can be used for the research of liver fibrosis.
For research use only. We do not sell to patients.
- Formula: C66H103N17O25
- Molecular Weight:1534.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Collagen I |
T2 peptide-1 (10 μM; 1 h) inhibits the Lumican-Collagen I interaction by 12.66[1].
T2 peptide-1 (10 μM; 24 h) reduces TGF-β1-induced Collagen I expression in human LX2 hepatic stellate cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human LX2 hepatic stellate cells (TGF-β1-stimulated)
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Concentration:10 μM
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Incubation Time:24 h
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Result:Reduced TGF-β1-induced COL1A1 protein levels in LX2 cells to a relative level of ~8 (normalized to GAPDH), which was lower than the TGF-β1-only group (relative level ~10).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male)[1]
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Dosage:1.0 mg/kg
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Administration:i.p.; single dose
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Result:Exhibited rapid elimination from circulation.
Chemical Information
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Molecular Weight 1534.62
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Formula C66H103N17O25
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Sequence
Tyr-Leu-Asp-Asn-Asn-Lys-Ile-Ser-Asn-Ile-Pro-Asp-Glu
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Sequence Shortening
YLDNNKISNIPDE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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