2. Neuronal Signaling
  3. Tau Protein Amyloid-β Cholinesterase (ChE)
  4. tau/Aβ40 aggregation-IN-1

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ40 aggregation inhibitor with IC50s of 1.8 μM and 1.3 μM, respectively.

For research use only. We do not sell to patients.

tau/Aβ40 aggregation-IN-1 Chemical Structure

tau/Aβ40 aggregation-IN-1 Chemical Structure

CAS No. : 2973377-10-3

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tau/Aβ40 aggregation-IN-1 Related Antibodies

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Description

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ40 aggregation inhibitor with IC50s of 1.8 μM and 1.3 μM, respectively[1].

IC50 & Target[1]

Aβ40 aggregation

1.3 μM (IC50)

tau aggregation

1.8 μM (IC50)

equine serum BChE

0.96 μM (IC50)

hAChE

16.10 μM (IC50)

In Vitro

tau/Aβ40 aggregation-IN-1 (Compound 20; 0.1-10 μM; 24 h) shows neuroprotective effect against Okadaic acid (HY-N6785)-induced tau toxicity in SH-SY5Y cells[1].
tau/Aβ40 aggregation-IN-1 inhibits electric eel AChE, human AChE and equine serum BChE with IC50s of 4.4, 16.10 and 0.96 μM, respectively. tau/Aβ40 aggregation-IN-1 shows 16% inhibition against human BChE at 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

tau/Aβ40 aggregation-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: Neuroblastoma cell line SH-SY5Y
Concentration: 0.1, 1, 5, 10 and 50 μM
Incubation Time: 24 h with Okadaic acid (100 nM)
Result: Exhibited a potent neuroprotective effect from 0.1 to 10 μM.
Molecular Weight

396.55

Formula

C23H28N2O2S
CAS No.
SMILES

COC1=CC=C2SC3=C(C(NCCC4CCN(CC4)C)=CC=C3C)C(C2=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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tau/Aβ40 aggregation-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

tau/Aβ40 aggregation-IN-12973377-10-3Tau ProteinAmyloid-βCholinesterase (ChE)β-amyloid peptideAβAbetaSH-SY5YneuroprotectiveOkadaic acidAChEBChEInhibitorinhibitorinhibit

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tau/Aβ40 aggregation-IN-1
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HY-149272
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