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Art. -Nr.: HY-149272

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tau/Aβ40 aggregation-IN-1

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ₄₀ aggregation inhibitor with IC₅₀s of 1.8 μM and 1.3 μM, respectively.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2973377-10-3
Formel: C₂₃H₂₈N₂O₂S
Molecular Weight:396.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

tau/Aβ40 aggregation-IN-1 Chemical Structure

CAS. Nr.: 2973377-10-3

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ₄₀ aggregation inhibitor with IC₅₀s of 1.8 μM and 1.3 μM, respectively^[1].

IC₅₀ & Target

^[1]

Aβ₄₀ aggregation

1.3 μM (IC₅₀)

tau aggregation

1.8 μM (IC₅₀)

equine serum BChE

0.96 μM (IC₅₀)

hAChE

16.10 μM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

tau/Aβ40 aggregation-IN-1 (Compound 20; 0.1-10 μM; 24 h) shows neuroprotective effect against Okadaic acid (HY-N6785)-induced tau toxicity in SH-SY5Y cells^[1].
tau/Aβ40 aggregation-IN-1 inhibits electric eel AChE, human AChE and equine serum BChE with IC₅₀s of 4.4, 16.10 and 0.96 μM, respectively. tau/Aβ40 aggregation-IN-1 shows 16% inhibition against human BChE at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[1]

View Protocol

Cell Line:

Neuroblastoma cell line SH-SY5Y
Concentration:

0.1, 1, 5, 10 and 50 μM
Incubation Time:

24 h with Okadaic acid (100 nM)
Result:

Exhibited a potent neuroprotective effect from 0.1 to 10 μM.

Chemical Information

CAS. Nr. 2973377-10-3
Molecular Weight 396.55
Formel C₂₃H₂₈N₂O₂S
SMILES

COC1=CC=C2SC3=C(C(NCCC4CCN(CC4)C)=CC=C3C)C(C2=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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