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Cat. No.: HY-149272

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tau/Aβ40 aggregation-IN-1

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ₄₀ aggregation inhibitor with IC₅₀s of 1.8 μM and 1.3 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 2973377-10-3
Formula: C₂₃H₂₈N₂O₂S
Molecular Weight:396.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

tau/Aβ40 aggregation-IN-1 Chemical Structure

CAS No.: 2973377-10-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ₄₀ aggregation inhibitor with IC₅₀s of 1.8 μM and 1.3 μM, respectively^[1].

IC₅₀ & Target^[1]

Aβ₄₀ aggregation

1.3 μM (IC₅₀)

tau aggregation

1.8 μM (IC₅₀)

equine serum BChE

0.96 μM (IC₅₀)

hAChE

16.10 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

tau/Aβ40 aggregation-IN-1 (Compound 20; 0.1-10 μM; 24 h) shows neuroprotective effect against Okadaic acid (HY-N6785)-induced tau toxicity in SH-SY5Y cells^[1].
tau/Aβ40 aggregation-IN-1 inhibits electric eel AChE, human AChE and equine serum BChE with IC₅₀s of 4.4, 16.10 and 0.96 μM, respectively. tau/Aβ40 aggregation-IN-1 shows 16% inhibition against human BChE at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Neuroblastoma cell line SH-SY5Y
Concentration:

0.1, 1, 5, 10 and 50 μM
Incubation Time:

24 h with Okadaic acid (100 nM)
Result:

Exhibited a potent neuroprotective effect from 0.1 to 10 μM.

Chemical Information

CAS No. 2973377-10-3
Molecular Weight 396.55
Formula C₂₃H₂₈N₂O₂S
SMILES

COC1=CC=C2SC3=C(C(NCCC4CCN(CC4)C)=CC=C3C)C(C2=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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