TLR7/8 agonist 7
TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist. TLR7/8 agonist 7 activates a variety of immune cells and it can be used to synthesize immune stimulating antibody conjugate (ISAC) molecules. TLR7/8 agonist 7 can be used for the research of immunity.
For research use only. We do not sell to patients.
- CAS No.: 2567953-47-1
- Formula: C26H37N7O2
- Molecular Weight:479.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 24 h) is a TLR7 agonist and shows selectivity to TLR7[1]. TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 120 h) shows no cytotoxicity to KB cells[1]. TLR7/8 agonist 7 (compound 10) (0.01, 0.1, 1, 10, 100 and 1000 nM; 48 h) induces immune cells activation[1]. TLR7/8 agonist 7 (compound 10) (0.1, 1, 10, 100 and 1000 nM; 24-48 h) induces cytokine release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293-humanTLR7 (hTLR7), HEK293-mouseTLR7 (mTLR7) and HEK293-humanTLR8 (hTLR8) cell lines
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Concentration:0-1000 nM
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Incubation Time:24 h
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Result:Showed selectivity to TLR7 and TLR8 as an agonist with EC50s of 1.5, 341.7 and 3.7nM in hTLR7, hTLR8 and mTLR7, respectively at 24 h.
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Cell Line:KB cells
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Concentration:0-1000 nM
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Incubation Time:120 h
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Result:Exhibited no cytotoxicity to KB cells though until concentration up to 1 μΜ.
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Cell Line:Human peripheral blood mononuclear cells (PBMCs), cyno PBMCs and mouse splenocytes
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Concentration:0.01, 0.1, 1, 10, 100 and 1000 nM
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Incubation Time:48 h
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Result:Activated immune cells (monocyte, B cell, and DCs) in human PBMCs, cyno PBMCs and mouse splenocytes.
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Cell Line:Human peripheral blood mononuclear cells (PBMCs), cyno PBMCs and mouse splenocytes
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Concentration:0.1, 1, 10, 100 and 1000 nM
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Incubation Time:24 and 48 h
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Result:Stimulated IL-6 , MCP-I , and ILlRa release from human PBMCs, IL-6 and MCP-I release from cyno PBMCs, as well as IL-6 , MCP-I , TNFa and IP-10 release from mouse splenocytes.
Chemical Information
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CAS No. 2567953-47-1
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Molecular Weight 479.62
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Formula C26H37N7O2
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SMILES
CCCCCNC1=NC(N)=NC2=C1N(CC3=CC=C(CN4CC5(C4)OCCNC5)C=C3OC)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7/8 agonist 7 Related Classifications
HY-147236 Related Classifications
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