1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. iGluR
    GABA Receptor
    Sodium Channel
    Calcium Channel
    Potassium Channel
    Carbonic Anhydrase
  3. Topiramate D12

Topiramate D12 (Synonyms: McN 4853 D12 ; RWJ 17021 D12)

Cat. No.: HY-110234
Handling Instructions

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

For research use only. We do not sell to patients.

Topiramate D12 Chemical Structure

Topiramate D12 Chemical Structure

CAS No. : 1279037-95-4

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Description

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

IC50 & Target

GluR5 receptor[1]; GABAergic[2]; Kainate/AMPA[2]; Sodium channel[2]; Calcium channel[2]; Potassium channel[2]; Carbonic anhydrase[2]

Molecular Weight

351.44

Formula

C₁₂H₉D₁₂NO₈S

CAS No.

1279037-95-4

SMILES

NS(OC[[email protected]]12[[email protected]](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O2)([H])[[email protected]@]3([H])[[email protected]@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O3)([H])CO1)(=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Topiramate D12McN 4853 D12 RWJ 17021 D12Topiramate D 12Topiramate D-12iGluRGABA ReceptorSodium ChannelCalcium ChannelPotassium ChannelCarbonic AnhydraseIonotropic glutamate receptorsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorNa channelsNa+ channelsCa2+ channelsCa channelsKcsACarbonate dehydrataseDeuteriumlabeledGluR5GABAergickainiteAMPAvoltage-sensitiveantiepilepticInhibitorinhibitorinhibit

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Topiramate D12
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