97240-79-4
97240-79-4
Chemical Structure
Topiramate
Synonym(s): McN 4853; RWJ 17021
- CAS. Nr.: 97240-79-4
- Formula:C12H21NO8S
- Molecular Weight:339.36
IUPAC Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl sulfamate
InChIKey: KJADKKWYZYXHBB-XBWDGYHZSA-N
SMILES: NS(OC[C@]1(OC(C)(C)O2)[C@@H]2[C@H](OC(C)(C)O3)[C@H]3CO1)(=O)=O
Biological Activity: Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Topiramate | 99.76% | Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. | ||||||||||||||||||||
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Topiramate (Standard) | 99.76% | Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. | ||||||||||||||||||||
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Topiramate-13C | Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. | |||||||||||||||||||||
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Topiramate-13C6-1 | Topiramate-13C6-1 (McN 4853-13C6-1; RWJ 17021-13C6-1) is 13C-labeled Topiramate (HY-B0122). | |||||||||||||||||||||
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Topiramate D12 | Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. | |||||||||||||||||||||
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Topiramate-13C6 | Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-B0122ATopiramate lithium -
Similarity Score 0.80
HY-W7001654,5-Desisopropylidene topiramate -
Similarity Score 0.79
HY-W011792RDiacetone-β-D-fructose (Standard) -
Similarity Score 0.69
HY-1668841,2:4,5-Bis-O-(1-methylethylidene)-β-D-psicopyranose -
Similarity Score 0.69
HY-N09791,2--4,5-Di-O-isopropylidene-β-D-fructopyranose -
Similarity Score 0.68
HY-41984Diacetone-D-glucose -
Similarity Score 0.68
HY-W0083351,2:5,6-Bis-O-(1-methylethylidene)-α-D-allofuranose -
Similarity Score 0.68
HY-W243018S1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6-13C6 -
Similarity Score 0.67
HY-W739878α-D-Galactofuranose,1,2:5,6-bis-O-(1-methylethylidene),acetate -
Explore the MedChemAI to find more analogs
References
- [1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104. [Content Brief]
- [2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56. [Content Brief]
- [3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7. [Content Brief]
