Topiramate lithium
Based on 9 publication(s) in Google Scholar
Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
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- CAS No.: 488127-53-3
- Formule: C12H21LiNO8S
- Masse moléculaire:346.30
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Topiramate lithium
More- Neuron. 2025 Aug 27:S0896-6273(25)00591-4. [Abstract]
- Cell Death Dis. 2025 Apr 5;16(1):253. [Abstract]
- Acta Pharmacol Sin. 2022 Dec;43(12):3139-3148. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Anal Chem. 2020 Dec 15;92(24):15745-15756. [Abstract]
- Sci Rep. 2025 Jul 2;15(1):22958. [Abstract]
- ETH Zurich. 2020 Dec.
- Personalized Medicine Universe. 2019 May.
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Activité biologique
Description
In Vitro
Topiramate lithium has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 488127-53-3
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Masse moléculaire 346.30
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Formule C12H21LiNO8S
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SMILES
NS(OC[C@]1(OC(C)(C)O2)[C@@H]2[C@H](OC(C)(C)O3)[C@H]3CO1)(=O)=O.[Li]
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Synonyms
McN 4853 lithium; RWJ 17021 lithium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Neuron
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth. [Abstract]2025 Aug 27:S0896-6273(25)00591-4. PMID: 40897174 -
Cell Death Dis
Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity. [Abstract]2025 Apr 5;16(1):253. PMID: 40185729 -
Acta Pharmacol Sin
SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs. [Abstract]2022 Dec;43(12):3139-3148. PMID: 35902765
Topiramate lithium purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2022 Dec;43(12):3139-3148. [Abstract]
Representative traces show the ramp currents of N1466T and N1466K mutants before and after treatment with 100 μM TPM (topiramate).
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Anal Chem
Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. [Abstract]2020 Dec 15;92(24):15745-15756. PMID: 33225709 -
Sci Rep
Effects of ATF2/TSC1 on epilepsy by modulating the microphages polarization of microglia. [Abstract]2025 Jul 2;15(1):22958. PMID: 40595935
Topiramate lithium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Jul 2;15(1):22958. [Abstract]
Topiramate (TPM: 100 μg/mL). Western blot analysis was performed to determine the protein expression of KA receptors GLUK5 and GLUK2.
Topiramate lithium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Jul 2;15(1):22958. [Abstract]
Compared to the KA-6 h group, HMC3 cells treated with Topiramate (TPM: 10 μg/mL) showed a decrease in CD80.
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Pureté et documentation
Références
[1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104. [Content Brief]
[2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56. [Content Brief]
[3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topiramate lithium Related Classifications
HY-B0122A Related Classifications
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