1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. iGluR
    GABA Receptor
    Sodium Channel
    Calcium Channel
    Potassium Channel
    Carbonic Anhydrase
  3. Topiramate lithium

Topiramate lithium (Synonyms: McN 4853 lithium; RWJ 17021 lithium)

Cat. No.: HY-B0122A
Handling Instructions

Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

For research use only. We do not sell to patients.

Topiramate lithium Chemical Structure

Topiramate lithium Chemical Structure

CAS No. : 488127-53-3

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Description

Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

In Vitro

Topiramate lithium has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

346.30

Formula

C12H21LiNO8S

CAS No.
SMILES

NS(OC[[email protected]]1(OC(C)(C)O2)[[email protected]@H]2[[email protected]](OC(C)(C)O3)[[email protected]]3CO1)(=O)=O.[Li]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Topiramate lithium
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