Topiramate-13C6
Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C613C6H21NO8S
- Masse moléculaire:345.32
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform iGluR
MoreVoir tous les produits spécifiques à Isoform Calcium Channel
More
Activité biologique
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
Unlabeled CAS 97240-79-4
-
Appearance Solid
-
Masse moléculaire 345.32
-
Formule C613C6H21NO8S
-
Color White to off-white
-
SMILES
NS(OC[C@]1(O[13C]([13CH3])([13CH3])O2)[C@@H]2[C@H](O[13C]([13CH3])([13CH3])O3)[C@H]3CO1)(=O)=O
-
Synonyms
McN 4853-13C6; RWJ 17021-13C6
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (289.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 4 mg/mL (11.58 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
-
Fiche technique (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56. [Content Brief]
[2]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104. [Content Brief]
[3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.8959 mL | 14.4793 mL | 28.9586 mL | 72.3966 mL |
| 5 mM | 0.5792 mL | 2.8959 mL | 5.7917 mL | 14.4793 mL | |
| 10 mM | 0.2896 mL | 1.4479 mL | 2.8959 mL | 7.2397 mL | |
| DMSO | 15 mM | 0.1931 mL | 0.9653 mL | 1.9306 mL | 4.8264 mL |
| 20 mM | 0.1448 mL | 0.7240 mL | 1.4479 mL | 3.6198 mL | |
| 25 mM | 0.1158 mL | 0.5792 mL | 1.1583 mL | 2.8959 mL | |
| 30 mM | 0.0965 mL | 0.4826 mL | 0.9653 mL | 2.4132 mL | |
| 40 mM | 0.0724 mL | 0.3620 mL | 0.7240 mL | 1.8099 mL | |
| 50 mM | 0.0579 mL | 0.2896 mL | 0.5792 mL | 1.4479 mL | |
| 60 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2066 mL | |
| 80 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9050 mL | |
| 100 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7240 mL |
Topiramate-13C6 Related Classifications
HY-B0122S Related Classifications
Powered by Bioz
Keywords
- Topiramate-13C6
- McN 4853-13C6
- RWJ 17021-13C6
- Isotope-Labeled Compounds
- Potassium Channel
- iGluR
- Sodium Channel
- GABA Receptor
- Carbonic Anhydrase
- Calcium Channel
- KcsA
- Ionotropic glutamate receptors
- Na channels
- Na+ channels
- Gamma-aminobutyric acid Receptor
- γ-Aminobutyric acid Receptor
- Carbonate dehydratase
- Ca2+ channels
- Ca channels
- Inhibitor
- inhibitor
- inhibit