AM4085
AM4085 is an orally active Antagonist for FmlH with an IC50 of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma.
For research use only. We do not sell to patients.
- Formula: C21H21F4NO6
- Molecular Weight:459.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
Pharmacokinetic Analysis of AM4085 in C3H/HeN mice[1]
| route | Dose (mg/kg) | C0 (ng/mL) | Cmax (ng/mL) | T1/2 (h) | Vdss (L/kg) | CL (mL/min/kg) | Tlast (h) | AUC0-last (ng·h/mL) | AUC0-inf (ng·h/mL) | MRT0-last (h) | MRT0-inf (h) | AUCExtra (%) | AUMCExtra (%) | F (%) |
| iv | 3 | 4427 | - | 1.47 | 1.42 | 13.6 | 8.0 | 3662 | 3736 | 1.59 | 1.75 | 1.90 | 10.8 | - |
| po | 10 | - | 1483 | 1.92 | - | - | 8.0 | 6070 | 6564 | 3.18 | 3.75 | 7.55 | 21.6 | 52.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 459.39
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Formula C21H21F4NO6
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SMILES
FC1=CC=C(C2=C(C(F)(F)F)C=CC=C2O[C@@H]3O[C@H](CO)[C@H](O)[C@@H](O)[C@H]3NC(C)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM4085 Related Classifications
HY-163291 Related Classifications
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