GHP-88309
Based on 1 Customer Validation
GHP-88309 is a broad-spectrum, orally active antiviral agent targeting paramyxoviruses, that targets the viral polymerase, interupts the viral RNA synthesis, and inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with EC50 of 0.06-1.2 μM. GHP-88309 exhibits anti-infectious efficacy in mouse models.
For research use only. We do not sell to patients.
- Purity : 99.69%
- CAS No.: 1269267-87-9
- Formula: C16H11FN2O
- Molecular Weight:266.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 1269267-87-9
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Appearance Solid
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Molecular Weight 266.27
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Formula C16H11FN2O
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Color White to off-white
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SMILES
O=C(C1=C(C=CC=C1C2=CC=CC3=C2C=CN=C3)F)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (187.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.7556 mL | 18.7779 mL | 37.5559 mL | 93.8897 mL |
| 5 mM | 0.7511 mL | 3.7556 mL | 7.5112 mL | 18.7779 mL | |
| 10 mM | 0.3756 mL | 1.8778 mL | 3.7556 mL | 9.3890 mL | |
| 15 mM | 0.2504 mL | 1.2519 mL | 2.5037 mL | 6.2593 mL | |
| 20 mM | 0.1878 mL | 0.9389 mL | 1.8778 mL | 4.6945 mL | |
| 25 mM | 0.1502 mL | 0.7511 mL | 1.5022 mL | 3.7556 mL | |
| 30 mM | 0.1252 mL | 0.6259 mL | 1.2519 mL | 3.1297 mL | |
| 40 mM | 0.0939 mL | 0.4694 mL | 0.9389 mL | 2.3472 mL | |
| 50 mM | 0.0751 mL | 0.3756 mL | 0.7511 mL | 1.8778 mL | |
| 60 mM | 0.0626 mL | 0.3130 mL | 0.6259 mL | 1.5648 mL | |
| 80 mM | 0.0469 mL | 0.2347 mL | 0.4694 mL | 1.1736 mL | |
| 100 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9389 mL |
GHP-88309 Related Classifications
HY-170395 Related Classifications
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