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Cat. No.: HY-172596

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TYK2 activator-1

TYK2 activator-1 (16b) is a TYK2 activator with anEC₅₀ of 1.78 μM. TYK2 activator-1 inhibits JAK2 and JAK3 with the IC₅₀ values of 6.8 and 6.3 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 3087219-47-1
Formula: C₂₂H₂₀FN₅O₂
Molecular Weight:405.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

TYK2 activator-1 Chemical Structure

CAS No.: 3087219-47-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TYK2 activator-1 (16b) is a TYK2 activator with anEC₅₀ of 1.78 μM. TYK2 activator-1 inhibits JAK2 and JAK3 with the IC₅₀ values of 6.8 and 6.3 μM, respectively^[1].

All JAK Isoforms :

Chemical Information

CAS No. 3087219-47-1
Molecular Weight 405.42
Formula C₂₂H₂₀FN₅O₂
SMILES

COC1=C(C#C)C=CC=C1NC2=CC(NC3=CC(C)=C(F)C=N3)=NC=C2C(NC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matsumoto H, et al. Identification of small molecule activators targeting TYK2 pseudokinase domain. Bioorg Med Chem Lett. 2025 Aug 1;123:130233. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TYK2 activator-1

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TYK2 activator-1 Related Classifications

HY-172596 Related Classifications