Tylophorinidine
Tylophorinidine is a natural phenanthroindolizidine alkaloid present in Tylophora ovata, and exhibits NFκB inhibitory activity. Tylophorinidine suppresses the cell viability of 3D co-culture spheroids derived from triple-negative breast cancer cells. Tylophorinidine is used in related research on triple-negative breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 32523-69-6
- Formula: C22H23NO4
- Molecular Weight:365.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
NF-κB 38.2 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
211.8 nM
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Inhibition of NFκB-mediated transcription in human triple-negative breast cancer MDA-MB-231 cells measured via NFκB-dependent luciferase reporter assay after 2 h of treatment.
Inhibition of NFκB-mediated transcription in human triple-negative breast cancer MDA-MB-231 cells measured via NFκB-dependent luciferase reporter assay after 2 h of treatment.
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36142230 |
| MDA-MB-231 | IC50 |
38.2 nM
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Inhibition of NFκB-mediated transcription in human triple-negative breast cancer MDA-MB-231 cells measured via NFκB-dependent luciferase reporter assay after 24 h of treatment.
Inhibition of NFκB-mediated transcription in human triple-negative breast cancer MDA-MB-231 cells measured via NFκB-dependent luciferase reporter assay after 24 h of treatment.
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36142230 |
| MDA-MB-231 | IC50 |
117.9 nM
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Reduction of cell viability in human triple-negative breast cancer MDA-MB-231 cells measured 24 h post-treatment.
Reduction of cell viability in human triple-negative breast cancer MDA-MB-231 cells measured 24 h post-treatment.
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36142230 |
In Vitro
Tylophorinidine (compound 2) inhibits NFκB-mediated transcription in MDA-MB-231 triple-negative breast cancer (TNBC) cells, with an IC50 of 38.2 nM at 24 h; it also reduces cell viability, with an IC50 of 117.9 nM at 24 h[1].
Tylophorinidine reduces the cell viability of MDA-MB-231/CAF 3D co-culture spheroids, with an IC50 of 441 nM after 72 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 32523-69-6
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Molecular Weight 365.42
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Formula C22H23NO4
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SMILES
O[C@H]1C2=C(C=CC(OC)=C3)C3=C(C=C(C(OC)=C4)O)C4=C2CN5[C@@]1([H])CCC5
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tylophorinidine Related Classifications
HY-W709923 Related Classifications
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