2. Inhibitory Antibodies
  3. Urtoxazumab

Urtoxazumab  (Synonyms: HuVTm1.1; TMA-15)

Cat. No.: HY-P99532

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Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against Shiga toxin (Stx) 2.

For research use only. We do not sell to patients.

Urtoxazumab Chemical Structure

Urtoxazumab Chemical Structure

CAS No. : 502496-16-4

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Description

Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against Shiga toxin (Stx) 2[1].

In Vivo

Urtoxazumab (TMA-15) (0.25-2.5 mg/kg; i.v.; once) ameliorates the lethal challenge in a time- and dose- dependent manner in B2F1-infected mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old male DBA/2J mice, STEC B2F1-infection model[1]
Dosage: 0.25, 0.5, 1.0, 2.0 and 2.5 mg/kg
Administration: Intravenous administration, 1 h before and 12, 24, and 48 h after infection
Result: Pretreatment completely protected the infected mice from death, the efficacy of the low dose (0.25 mg/kg) was partial when administered at 12 and 24 h after infection, but the efficacy of the high dose (2.5 mg/kg) was still complete. Prevented death from B2F1 infection in all 20 animals at 1.0 and 2.0 mg/kg 24 h after infection.
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[Urtoxazumab]
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urtoxazumab502496-16-4HuVTm1.1 TMA-15TMA15TMA 15TMA-15OthersB2F1Stx2DBA/2J miceInhibitorinhibitorinhibit

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