SLC10A4 - solute carrier family 10 member 4 Gene

Also Known as P4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201780

About SLC10A4

Cytogenetic location: 4p11 Genomic coordinates (GRCh38): 4:48,483,343-48,489,526 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 5 paralogues. Biased expression in adrenal (RPKM 2.6), brain (RPKM 1.4) and 8 other tissues.

Summary

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport and regulation of neurotransmitter loading into synaptic vesicle. Predicted to act upstream of or within adult behavior and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cholinergic synapse; dopaminergic synapse; and serotonergic synapse. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC10A4 Products (1)

mRNA Protein Name
NM_152679.4 NP_689892.1 sodium/bile acid cotransporter 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC10A4 Protein Structure

SBF

SBF: Sodium Bile acid symporter family (112 - 287)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
Protein Preferred Names Protein Names

sodium/bile acid cotransporter 4

  • Na(+)/bile acid cotransporter 4

SLC10A4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC10A4 Q96EP9 SLC35A4 Homo sapiens Q96G79
Validated Y2H
32296183
Intra
SLC10A4 Q96EP9 DNAJC30 Homo sapiens Q96LL9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12990 SLC10A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC10A4 VGNC VGNC:34661
Mus musculus SLC10A4 MGD MGI:3606480
Rattus norvegicus SLC10A4 RGD RGD:1309536
Felis catus SLC10A4 VGNC VGNC:65183
Macaca mulatta SLC10A4 VGNC VGNC:77553
Canis familiaris SLC10A4 VGNC VGNC:51782
Others SLC10A4 NCBI