Ryk - receptor-like tyrosine kinase Gene

Also Known as Vik; ERK-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20187

Summary

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and Frizzled binding activity. Involved in nervous system development. Acts upstream of or within generation of neurons; negative chemotaxis; and skeletal system morphogenesis. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ryk Products (3)

mRNA Protein Name
NM_001042607.1 NP_001036072.1 tyrosine-protein kinase RYK isoform 2 precursor
NM_001284258.1 NP_001271187.1 tyrosine-protein kinase RYK isoform 3
NM_013649.3 NP_038677.3 tyrosine-protein kinase RYK isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IPI
IPI: Inferred from physical interaction
15454084 MGI
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
15454084 MGI
enables frizzled binding IPI
IPI: Inferred from physical interaction
15454084 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10932185 MGI
NOT enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
1334548 MGI
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway IDA
IDA: Inferred from direct assay
15454084 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16723543 MGI
acts upstream of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
16723543 MGI
involved in axon guidance IDA
IDA: Inferred from direct assay
16116452 MGI
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
16723543 MGI
acts upstream of or within axonogenesis IGI
IGI: Inferred from genetic interaction
15454084 MGI
involved in chemorepulsion of dopaminergic neuron axon IGI
IGI: Inferred from genetic interaction
23517308 MGI
acts upstream of or within commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
16723543 MGI
involved in corpus callosum development IMP
IMP: Inferred from mutant phenotype
16723543 MGI
involved in midbrain dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
23517308 MGI
acts upstream of or within negative chemotaxis IGI
IGI: Inferred from genetic interaction
16723543 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
16723543 MGI
involved in neuron differentiation IDA
IDA: Inferred from direct assay
19000841 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
15454084 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
10932185 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19000841 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34407949 MGI
located in membrane IDA
IDA: Inferred from direct assay
8394755 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19000841 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
7822791 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
34407949 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
34407949 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase RYK

  • NYK-R

  • growth factor receptor

  • kinase VIK

  • met-related kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12367 RYK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18743 Ryk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25230 Ryk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ryk NCBI NCBI:6259