SND1 - staphylococcal nuclease and tudor domain containing 1 Gene

Also Known as p100; TDRD11; Tudor-SN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27044

About SND1

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,652,194-128,092,593 (from NCBI)

This gene has 16 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 81 phenotypes. Ubiquitous expression in placenta (RPKM 45.9), thyroid (RPKM 41.6) and 25 other tissues.

Summary

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and Other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

SND1 Products (1)

mRNA Protein Name
NM_014390.4 NP_055205.2 staphylococcal nuclease domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RISC complex binding IDA
IDA: Inferred from direct assay
28546213 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
18453631 GOA
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
28546213 GOA
enables endonuclease activity IDA
IDA: Inferred from direct assay
18453631 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20643132 GOA
Biological Process GO Annotation Evidence References Source
involved in miRNA catabolic process IDA
IDA: Inferred from direct assay
28546213 GOA
involved in regulation of cell cycle process IMP
IMP: Inferred from mutant phenotype
28546213 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SND1 Protein Structure

SNase

SNase: Staphylococcal nuclease homologue (50 - 166)

SNase

SNase: Staphylococcal nuclease homologue (220 - 327)

SNase

SNase: Staphylococcal nuclease homologue (368 - 495)

SNase

SNase: Staphylococcal nuclease homologue (553 - 659)

TUDOR

TUDOR: Tudor domain (679 - 796)

SNase

SNase: Staphylococcal nuclease homologue (848 - 894)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 910 a.a.
Protein Preferred Names Protein Names

staphylococcal nuclease domain-containing protein 1

  • EBNA2 coactivator p100

SND1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SND1 Q7KZF4 MTDH Homo sapiens Q86UE4
Anti Bait CoIP
24981741
Intra
SND1 Q7KZF4 MTDH Homo sapiens Q86UE4
Anti Tag CoIP
24981741
Intra
SND1 Q7KZF4 MTDH Homo sapiens Q86UE4
Pull Down
24981741
Intra
SND1 Q7KZF4 G3BP1 Homo sapiens Q13283
Anti Bait CoIP
20643132
Intra
SND1 Q7KZF4 PIWIL1 Homo sapiens Q96J94
FPS
20937909
Intra
SND1 Q7KZF4 PIWIL1 Homo sapiens Q96J94
ITC
20937909
Intra
SND1 Q7KZF4 PIWIL1 Homo sapiens Q96J94
X-Ray Diffraction
20937909
Cross: Cross-species interaction Intra: Intraspecies interaction

SND1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84653 SND1/P100 Antibody (YA4350) WB, ELISA Human
HY-P84653A SND1/P100 Antibody (YA4350)(PBS only) WB, ELISA Human
HY-P85400 SND1/P100 Antibody (YA5092) WB, ELISA Human

Related Diseases

Diseases Alias
Posterior Pituitary Gland Neoplasm

  • Posterior Pituitary Tumor

  • Neoplasm Of The Posterior Pituitary
Pancreatic Acinar Cell Adenocarcinoma

  • Pancreatic Acinar Cell Carcinoma

  • Acinar Cell Adenocarcinoma Of The Pancreas
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155170 MTDH-SND1 blocker 1 Inhibitor 99.33% Unkown
HY-115581A Thymidine 3',5'-diphosphate tetrasodium 98.75% Unkown
HY-160801 HKYK-0030 Inhibitor 99.38% Unkown
HY-168850 MTDH-SND1 blocker 2 Inducer 99.51% Unkown
HY-RS13488 SND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17496 Snd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115581 Thymidine 3',5'-disphosphate Inducer / Unkown
HY-RS23953 Snd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SND1 MGD MGI:1929266
Rattus norvegicus SND1 RGD RGD:631340
Bos taurus SND1 VGNC VGNC:35063
Macaca mulatta SND1 VGNC VGNC:77798
Felis catus SND1 VGNC VGNC:65528
Canis familiaris SND1 VGNC VGNC:46600
Others SND1 NCBI