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F11R - F11 receptor Gene

Also Known as JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50848

About F11R

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,995,211-161,021,152 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 14 paralogues. Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the Integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

F11R Products (6)

mRNA	Protein	Name
NM_001348091.2	NP_001335020.1	junctional adhesion molecule A isoform 6 precursor
NM_001382727.1	NP_001369656.1	junctional adhesion molecule A isoform 7 precursor
NM_001382730.1	NP_001369659.1	junctional adhesion molecule A isoform 8 precursor
NM_001382733.1	NP_001369662.1	junctional adhesion molecule A isoform 9 precursor
NM_001382734.1	NP_001369663.1	junctional adhesion molecule A isoform 10 precursor
NM_016946.6	NP_058642.1	junctional adhesion molecule A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	23885123	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	11812992	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15344881	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14749337	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	14749337	GOA
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	26985018	GOA
involved in establishment of endothelial intestinal barrier	IGI IGI: Inferred from genetic interaction	23885123	GOA
involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in intestinal absorption	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	11812992	GOA
involved in memory T cell extravasation	IDA IDA: Inferred from direct assay	11812992	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	26985018	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	26985018	GOA
involved in positive regulation of platelet aggregation	IDA IDA: Inferred from direct assay	15344881	GOA
involved in protein localization to bicellular tight junction	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15344881	GOA
involved in regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	15344881	GOA
involved in regulation of cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25753039	GOA
involved in regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	23885123	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	23885123	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11812992	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15344881	GOA
located in tight junction	IMP IMP: Inferred from mutant phenotype	14749337	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F11R Protein Structure

V-set

Ig_2

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
junctional adhesion molecule A	junctional adhesion molecule 1

F11R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	F11R	Q9Y624	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	F11R	Q9Y624	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	F11R	Q9Y624	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	F11R	Q9Y624	SGTA	Homo sapiens	O43765	Y2H	21516116
Intra	F11R	Q9Y624	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	F11R	Q9Y624	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant F11R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70948	JAM-A/CD321 Protein, Human (HEK293, His)	Q9Y624-1 (S28-V238)	≥ 95%, as determined by reducing SDS-PAGE.

F11R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83280	Junctional Adhesion Molecule 1 Antibody (YA3025)	WB, ICC/IF, IP, FC	Human
HY-P83280A	Junctional Adhesion Molecule 1 Antibody (YA3025)(PBS only)	WB, ICC/IF, IP	Human
HY-P84900	Junctional Adhesion Molecule 1 Antibody (YA4597)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84900A	Junctional Adhesion Molecule 1 Antibody (YA4597)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Nemaline Myopathy 4	Cap Myopathy 2 NEM4 Nemaline Myopathy 4, Autosomal Dominant Nemaline Myopathy, Type 4 CAPM2 Cap Disease Cap Myopathy Tpm2-Related Tpm2-Related Nemaline Myopathy Tpm2-Related Cap Myopathy Myopathy, Nemaline, Type 4 Cap Myopathy
Purulent Acute Otitis Media	Acute Suppurative Otitis Media Acute Or Subacute Suppurative Otitis Media Acute Or Subacute Purulent Otitis Media
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04626	F11R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19600	F11r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26096	F11r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	F11R	VGNC	VGNC:56143
Macaca mulatta	F11R	VGNC	VGNC:72272
Mus musculus	F11R	MGD	MGI:1321398
Bos taurus	F11R	VGNC	VGNC:50010
Felis catus	F11R	VGNC	VGNC:109510
Rattus norvegicus	F11R	RGD	RGD:621842
Others	F11R	NCBI