STRN - striatin Gene

Also Known as SG2NA; STRN1; PPP2R6A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6801

About STRN

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,837,698-36,966,536 (from NCBI)

This gene has 3 transcripts (splice variants), 271 orthologues, 2 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 6.7), brain (RPKM 5.1) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity; Estrogen receptor binding activity; and protein Phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN Products (1)

mRNA Protein Name
NM_003162.4 NP_003153.2 striatin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
18502210 GOA
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
15569929 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17540176 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
18782753 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18782753 GOA
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18502210 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18502210 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
18502210 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN Protein Structure

Striatin

Striatin: Striatin family (48 - 179)

WD40

WD40: WD domain, G-beta repeat (453 - 491)

WD40

WD40: WD domain, G-beta repeat (507 - 544)

WD40

WD40: WD domain, G-beta repeat (565 - 597)

WD40

WD40: WD domain, G-beta repeat (696 - 734)

WD40

WD40: WD domain, G-beta repeat (753 - 779)

  • 0
  • 200
  • 400
  • 600
  • 780 a.a.
Protein Preferred Names Protein Names

striatin

  • protein phosphatase 2 regulatory subunit B'''alpha

STRN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STRN O43815 STRN3 Homo sapiens Q13033
Anti Tag CoIP
18782753
Intra
STRN O43815 STRN3 Homo sapiens Q13033
Anti Tag CoIP
33961781
Intra
STRN O43815 STRN3 Homo sapiens Q13033
Anti Tag CoIP
26496610
Intra
STRN O43815 STRN3 Homo sapiens Q13033
Anti Bait CoIP
18782753
Intra
STRN O43815 STRN3 Homo sapiens Q13033
Anti Tag CoIP
24366813
Intra
STRN O43815 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
24366813
Intra
STRN O43815 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
26496610
Intra
STRN O43815 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
33961781
Intra
STRN O43815 CTTNBP2NL Homo sapiens Q9P2B4
Anti Tag CoIP
18782753
Intra
STRN O43815 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
33961781
Intra
STRN O43815 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
26496610
Intra
STRN O43815 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
18782753
Intra
STRN O43815 TNKS2 Homo sapiens Q9H2K2
FPS
22153077
Intra
STRN O43815 STK25 Homo sapiens O00506
Anti Tag CoIP
18782753
Intra
STRN O43815 PPP2CA Homo sapiens P67775
Anti Tag CoIP
33961781
Intra
STRN O43815 PPP2CA Homo sapiens P67775
Anti Tag CoIP
18782753
Intra
STRN O43815 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
24366813
Intra
STRN O43815 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
18782753
Intra
STRN O43815 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
33961781
Intra
STRN O43815 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
26496610
Intra
STRN O43815 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
25416956
Intra
STRN O43815 RINT1 Homo sapiens Q6NUQ1
Y2H Array
25416956
Intra
STRN O43815 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
18782753
Intra
STRN O43815 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
33961781
Intra
STRN O43815 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
26496610
Intra
STRN O43815 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
18782753
Intra
STRN O43815 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
33961781
Intra
STRN O43815 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
24366813
Intra
STRN O43815 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Metanephric Adenoma
Renal Adenoma

  • Renal Cell Adenoma
Peritoneal Mesothelioma

  • Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Peritoneal Mesothelioma

  • Advanced Peritoneal Malignant Mesothelioma
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Thyroid Gland Anaplastic Carcinoma

  • Anaplastic Thyroid Carcinoma

  • Anaplastic Thyroid Cancer

  • Thyroid Cancer, Anaplastic

  • Thyroid Carcinoma, Anaplastic

  • Thyroid Carcinoma Anaplastic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13967 STRN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13966 STRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13968 STRN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22334 Strn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28856 Strn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta STRN VGNC VGNC:78039
Rattus norvegicus STRN RGD RGD:3782
Bos taurus STRN VGNC VGNC:35424
Canis familiaris STRN VGNC VGNC:46945
Mus musculus STRN MGD MGI:1333757
Felis catus STRN VGNC VGNC:81230
Others STRN NCBI