2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. VcMMAE-Eribulin

VcMMAE-Eribulin is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Eribulin (HY-13442) (Microtubule inhibitor). VcMMAE-Eribulin can be used for ADC synthesis.

For research use only. We do not sell to patients.

VcMMAE-Eribulin

VcMMAE-Eribulin Chemical Structure

CAS No. : 2760408-69-1

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Based on 1 publication(s) in Google Scholar

VcMMAE-Eribulin Related Antibodies

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Description

VcMMAE-Eribulin is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Eribulin (HY-13442) (Microtubule inhibitor). VcMMAE-Eribulin can be used for ADC synthesis.

IC50 & Target

Dual payloads

 

Molecular Weight

2549.04

Formula

C131H194N18O33
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=C1C[C@@]2([H])O[C@@]1([H])CC[C@]3([H])O[C@](C([C@H](C)C3)=C)([H])C[C@@]4([H])[C@]([C@@H](OC)[C@@H](C[C@H](O)CNC(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CC(C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C8=CC=CC=C8)=O)([H])CCC7)=O)C)=O)=O)=O)C=C6)=O)=O)=O)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)=O)C=C5)=O)O4)([H])CC(C[C@]%10([H])O[C@]%11([H])[C@]%12([H])O[C@@]%13(O[C@@]%14([H])[C@@](O[C@]%12([H])[C@@]%14([H])O[C@@]%11([H])CC%10)([H])C%13)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (39.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3923 mL 1.9615 mL 3.9230 mL
5 mM 0.0785 mL 0.3923 mL 0.7846 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3923 mL 1.9615 mL 3.9230 mL 9.8076 mL
5 mM 0.0785 mL 0.3923 mL 0.7846 mL 1.9615 mL
10 mM 0.0392 mL 0.1962 mL 0.3923 mL 0.9808 mL
15 mM 0.0262 mL 0.1308 mL 0.2615 mL 0.6538 mL
20 mM 0.0196 mL 0.0981 mL 0.1962 mL 0.4904 mL
25 mM 0.0157 mL 0.0785 mL 0.1569 mL 0.3923 mL
30 mM 0.0131 mL 0.0654 mL 0.1308 mL 0.3269 mL
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VcMMAE-Eribulin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VcMMAE-Eribulin2760408-69-1SMP13432SMP 13432SMP-13432Drug-Linker Conjugates for ADCMicrotubule/TubulinEribulinMMAEADCInhibitorinhibitorinhibit

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