2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-37

VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2. The inhibition rate at 200 μM was approximately 56.9 μM. VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation.

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VEGFR-2-IN-37 Chemical Structure

VEGFR-2-IN-37 Chemical Structure

CAS No. : 298207-77-9

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Based on 1 publication(s) in Google Scholar

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Description

VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2. The inhibition rate at 200 μM was approximately 56.9 μM. VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation[1].

IC50 & Target

VEGFR-2[1]
Molecular Weight

324.40

Formula

C18H16N2O2S
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C)C1=CC(OC2=NC=NC3=C2C(CCCC4)=C4S3)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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VEGFR-2-IN-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-37298207-77-9VEGFRVascular endothelial growth factor receptorVascular endothelial growth factor receptor 2VEGFR-2Anti-angiogenic activityStructure-based drug designSBDDLigand-based drug design,LBDD3-D QSARThieno[3,2-d]pyrimidinoneThieno[1,2,3]triazineEndothelial cell tube formationInhibitorinhibitorinhibit

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