VEGFR-2-IN-44
VEGFR-2-IN-44 (compound 4b) is a selective VEGF-R2 (Flk-1) inhibitor with an IC50 value of 70 nM. VEGFR-2-IN-44 also inhibits PDGF-Rβ with an IC50 of 920 nM.
For research use only. We do not sell to patients.
- CAS No.: 288144-20-7
- Formula: C17H15BrN2O
- Molecular Weight:343.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
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Flk-1 70 nM (IC50) |
PDGFR-β 920 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
>50 μM
Compound: 4b
|
Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells
|
[PMID: 10893303] |
| HUVEC | IC50 |
0.11 μM
Compound: 4b
|
Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells
|
[PMID: 10893303] |
| HUVEC | IC50 |
2.01 μM
Compound: 4b
|
Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells
|
[PMID: 10893303] |
| HUVEC | IC50 |
24.6 μM
Compound: 4b
|
Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells
Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells
|
[PMID: 10893303] |
Chemical Information
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CAS No. 288144-20-7
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Molecular Weight 343.22
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Formula C17H15BrN2O
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SMILES
O=C(/C(C1=C2)=C\C3=CC4=C(CCCC4)N3)NC1=CC=C2Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)