2. Apoptosis Others
  3. Ferroptosis Drug Derivative
  4. WMK-1

WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

WMK-1

WMK-1 Chemical Structure

CAS No. : 2814563-83-0

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WMK-1 Related Antibodies

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Description

WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer[1].

In Vitro

WMK-1 (compound 48) (48 h) potently inhibits viability of MDA-MB-231, Hela, T47D, Jurkat, HCT116, and HL-60 cancer cells with IC50 values ranging from 1.0 μM to 6.3 μM[1].
WMK-1 (48 h) potently inhibits viability of HeyA8 ovarian cancer cells (IC50 = 2.3 μM) and HeyA8sp ovarian cancer stem cell spheres (IC50 = 1.2 μM)[1].
WMK-1 (24 h) induces ferroptosis in HeyA8 ovarian cancer cells, HeyA8 ovarian cancer stem cells, and HeyA8 ovarian cancer stem cell spheres[1].
WMK-1 (5 μM; 6 h) increases lipid reactive oxygen species levels in MDA-MB-231 triple negative breast cancer cells[1].
WMK-1 (5 μM) induced cell death in MDA-MB-231 triple-negative breast cancer cells at indicated concentrations within 24 h, and this effect was significantly reversed by 30 μM liproxstatin-1 (HY-12726) pretreatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WMK-1 Related Antibodies
In Vivo

WMK-1 (compound 48) (5-10 mg/kg, i.p.) reduced tumor burden in both ovarian cancer and triple-negative breast cancer xenograft models in nude mice, with no observable systemic or organ-related toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (female)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.
Result: Reduced ovarian cancer xenograft tumor size.
Caused no abnormal behavior or weight loss in treated animals during the entire study period.
Molecular Weight

722.69

Formula

C35H51IN2O6
CAS No.
SMILES

CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[N+](CC4=CC=CC=C4)(C)CC5=CC=CC=C5)=O)CC3)OO2)CC1.[I-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WMK-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WMK-12814563-83-0WMK1WMK 1FerroptosisDrug DerivativeDrug derivativeMDA-MB-231cancer cellsovarian cancerbreast cancerNIH3T3ferroptosiscolon cancercancer stem cellsleukemiaHelaInhibitorinhibitorinhibit

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