Y-33075 hydrochloride
Based on 14 publication(s) in Google Scholar
Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
For research use only. We do not sell to patients.
- CAS No.: 471843-75-1
- Formula: C16H17ClN4O
- Molecular Weight:316.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Y-33075 hydrochloride
More- Science. 2017 Dec 1;358(6367):eaan4368. [Abstract]
- Cell. 2018 Jul 26;174(3):636-648.e18. [Abstract]
- Nat Commun. 2020 Jan 3;11(1):88. [Abstract]
- J Adv Res. 2024 Sep:63:117-128. [Abstract]
- Adv Sci (Weinh). 2022 May;9(13):e2104682. [Abstract]
- Cell Death Dis. 2024 Dec 26;15(12):932. [Abstract]
- Acta Neuropathol Commun. 2024 Sep 14;12(1):150. [Abstract]
- Cells. 2024 Nov 18;13(22):1907. [Abstract]
- Stem Cell Reports. 2020 Jan 14;14(1):49-59. [Abstract]
- J Cell Physiol. 2021 Dec;236(12):8226-8238. [Abstract]
- Neurotox Res. 2013 Apr;23(3):238-48. [Abstract]
- PLoS One. 2023 Jan 31;18(1):e0270288. [Abstract]
- bioRxiv. 2025 June 03.
- Patent. US20170349879A1.
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Cell Proliferation/Viability Assay
Biological Activity
Description
In Vitro
Y-33075 hydrochloride (Y-39983) (10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983[2]. Y-33075 hydrochloride (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions. Y-33075 hydrochloride (10 μM) shows no effect on the [Ca2+]i increase with the high-potassium (high-K) solution[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 471843-75-1
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Molecular Weight 316.79
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Formula C16H17ClN4O
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SMILES
O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.Cl
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Synonyms
Y-39983
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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Science
2017 Dec 1;358(6367):eaan4368. PMID: 29191878 -
Cell
2018 Jul 26;174(3):636-648.e18. PMID: 30017246 -
Nat Commun
2020 Jan 3;11(1):88. PMID: 31900402 -
J Adv Res
Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling. [Abstract]2024 Sep:63:117-128. PMID: 37806546 -
Adv Sci (Weinh)
Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. [Abstract]2022 May;9(13):e2104682. PMID: 35240008 -
Cell Death Dis
TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the Notch signaling pathway. [Abstract]2024 Dec 26;15(12):932. PMID: 39725730 -
Acta Neuropathol Commun
Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model. [Abstract]2024 Sep 14;12(1):150. PMID: 39300576 -
Cells
Thrombospondin 1 Mediates Autophagy Upon Inhibition of the Rho-Associated Protein Kinase Inhibitor. [Abstract]2024 Nov 18;13(22):1907. PMID: 39594655 -
Stem Cell Reports
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity. [Abstract]2020 Jan 14;14(1):49-59. PMID: 31883921 -
J Cell Physiol
2021 Dec;236(12):8226-8238. PMID: 34180057 -
Neurotox Res
The Rho-kinase (ROCK) inhibitor Y-27632 protects against excitotoxicity-induced neuronal death in vivo and in vitro. [Abstract]2013 Apr;23(3):238-48. PMID: 22810835
Y-33075 hydrochloride purchased from MedChemExpress. Usage Cited in: Neurotox Res. 2013 Apr;23(3):238-48. [Abstract]
Effect of Y39983 on glutamate-treated HT22 cell viability.
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PLoS One
The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells. [Abstract]2023 Jan 31;18(1):e0270288. PMID: 36719899
Y-33075 hydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2023 Jan 31;18(1):e0270288. [Abstract]
Y-27632 (10, 100 nM and 10, 100 µM; 24 h) decreases phosphorylation of MLC starting at a concentration of 100 nM in HSCs.
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Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. [Content Brief]
[2]. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Y-33075 hydrochloride Related Classifications
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