YHIEPV
Based on 1 Customer Validation
YHIEPV (rALP-2, Rubisco anxiolytic-like peptide 2) is a potent and orally active peptide. YHIEPV shows anxiolytic effects. YHIEPV increases leptin sensitivity to exert its anti-obesity effects.
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- Pureté : 99.85%
- CAS No.: 2243939-21-9
- Formule: C36H52N8O10
- Masse moléculaire:756.85
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
YHIEPV (0.3, 1 mM; 30 min) suppresses an increase in intracellular cAMP levels stimulated by forskolin (HY-15371) (10 μM) in a dose-dependent manner in Neuro-2a cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2243939-21-9
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Appearance Solid
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Masse moléculaire 756.85
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Formule C36H52N8O10
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Color White to off-white
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Synonyms
rALP-2, Rubisco anxiolytic-like peptide 2
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Sequence
Tyr-His-Ile-Glu-Pro-Val
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Sequence Shortening
YHIEPV
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (132.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kimura S, et al. Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1050-1056. [Content Brief]
[2]. Kaneko K, et al. An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness. Sci Rep. 2022 May 21;12(1):8599. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3213 mL | 6.6063 mL | 13.2127 mL | 33.0316 mL |
| 5 mM | 0.2643 mL | 1.3213 mL | 2.6425 mL | 6.6063 mL | |
| 10 mM | 0.1321 mL | 0.6606 mL | 1.3213 mL | 3.3032 mL | |
| 15 mM | 0.0881 mL | 0.4404 mL | 0.8808 mL | 2.2021 mL | |
| 20 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.6516 mL | |
| 25 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.3213 mL | |
| 30 mM | 0.0440 mL | 0.2202 mL | 0.4404 mL | 1.1011 mL | |
| 40 mM | 0.0330 mL | 0.1652 mL | 0.3303 mL | 0.8258 mL | |
| 50 mM | 0.0264 mL | 0.1321 mL | 0.2643 mL | 0.6606 mL | |
| 60 mM | 0.0220 mL | 0.1101 mL | 0.2202 mL | 0.5505 mL | |
| 80 mM | 0.0165 mL | 0.0826 mL | 0.1652 mL | 0.4129 mL | |
| 100 mM | 0.0132 mL | 0.0661 mL | 0.1321 mL | 0.3303 mL |
YHIEPV Related Classifications
HY-P10397 Related Classifications
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