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Cat. No.: HY-184294

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ZH25

ZH25 is an ATR kinase inhibitor with antiproliferative activity against ATM-deficient cancer cells. ZH25 induces DNA damage, reduces G₂/M phase cell proportion, upregulates γH2AX, Cleaved-Caspase3, and Cleaved-PARP. ZH25 functions as an ATR kinase binding ligand for ATR-PROTAC degrader design. ZH25 can be used for the research of atm-deficient cancer.

For research use only. We do not sell to patients.

CAS No.: 3037598-39-0
Formula: C₂₀H₂₃N₅O
Molecular Weight:349.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

ZH25 Chemical Structure

CAS No.: 3037598-39-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All ATM/ATR Isoforms :

In Vitro

ZH25 (72 h) inhibits the proliferation of ATM-deficient LoVo cells with an IC₅₀ of 32.8 μM, but has no activity against ATM-proficient HCT116 cells or normal NCM460 cells^[1].
ZH25 (72 h) does not inhibit the proliferation of ATM-deficient NCI-H23 or GRANTA-519 cells, with IC₅₀ values >50 μM for both cell lines^[1].
ZH25 (10 μM; 72 h) induces a small increase in DNA damage in LoVo cells, and induces less DNA damage than the ATR degrader I-1 at lower concentrations^[1].
ZH25 (10 μM; 48 h) induces apoptosis in LoVo cells, and induces less apoptosis than the ATR degrader I-1 at 5 μM^[1].
ZH25 (10 μM; 48 h) reduces the proportion of LoVo cells in the G2/M phase^[1].
ZH25 (6.25-25 μM; 24 h) slightly upregulates DNA damage and apoptosis markers in LoVo cells, with weaker activity than the ATR degrader I-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3037598-39-0
Molecular Weight 349.43
Formula C₂₀H₂₃N₅O
SMILES

C[C@@H]1COCCN1C2=NC(C3=CC=CC4=C3C=CN4)=NC5=C2CCNC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang L, et al. Discovery of a selective and effective CRBN-recruiting ATR degrader with strong antitumor activity. European journal of medicinal chemistry. 2026 Oct 05;315:118976. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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ZH25

All ATM/ATR Isoforms