α-CGRP (human) TFA
Based on 6 publication(s) in Google Scholar
α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.32%
- 分子式: C163H267N51O49S2·xC2HF3O2
- 分子量:3789.31 (free base)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* The compound is unstable in solutions, freshly prepared is recommended.
MedChemExpress(MCE)の使用を引用している文献 α-CGRP (human) TFA
More- J Nanobiotechnology. 2026 May 16;24(1):645. [Abstract]
- Mater Today Bio. 2026 Mar 31:38:103067. [Abstract]
- Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
- Int J Pharm. 2026 Jul 10:700:127062. [Abstract]
- Int Immunopharmacol. 2024 Mar 30:130:111766. [Abstract]
- Sci Rep. 2024 Nov 2;14(1):26385. [Abstract]
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WB
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Flow Cytometry
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IF
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Others
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ELISA
生物活性
製品説明
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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性状 Solid
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分子量 3789.31 (free base)
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分子式 C163H267N51O49S2·xC2HF3O2
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Color White to off-white
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別名
Calcitonin gene-related peptide TFA
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配列
Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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シーケンスの短縮
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (Disulfide bridge:Cys2-Cys7)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * The compound is unstable in solutions, freshly prepared is recommended.
Publications (6)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
All-in-one: a CGRP-encapsulated Rh-GelMA supramolecular dual-network hydrogel orchestrating immune-vascular coupling for diabetic wound healing. [Abstract]2026 May 16;24(1):645. PMID: 42143359 -
Mater Today Bio
CGRP-empowered stem cell sheet/short nanofiber sponge via enhancing neurovascular coupling for bone regeneration. [Abstract]2026 Mar 31:38:103067. PMID: 42006713 -
Free Radic Biol Med
Oxidative stress impairs the expansion of regulatory T cells in active vitiligo via dysregulated CGRP-RAMP1-Gαi3 signaling. [Abstract]2025 Dec 24:245:18-29. PMID: 41453541
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative Western blot images showing the expression levels of PCNA, phosphorylated CREB (pCREB, Ser133), total CREB, and Gαi3 proteins in MT-2 Treg-like cells transfected with control or RAMP1-specific shRNA and treated with 1 μg/mL CGRP or 50 μM H2O2 for 24 h. β-actin was used as an internal control.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative CFSE-labeled flow cytometry plots of MT-2 Tregs treated with the indicated concentrations of CGRP (0-3 μg/mL) in the absence (upper panels) or presence (lower panels) of 50 μM H2O2.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). X-gal staining and immunofluorescence of tail skin sections from each group. Upper panels: X-gal staining visualizing MCs (black arrows); black dashed lines indicate borders between depigmented and normally pigmented areas. Lower panels: Immunofluorescence staining of FOXP3+ Tregs (green) with nuclei labeled by DAPI (blue); white dashed lines denote the dermal-epidermal junction, and white arrows indicate FOXP3+ Tregs.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). Representative macroscopic and Wood’s lamp images of tail skin from each group.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (10 nM, 72 h) regulates TGF-β and IL-10 production in Tregs. Levels of TGF-β and IL-10 in Treg culture supernatants were measured by ELISA.
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Int J Pharm
Electrospun PCL/PVA core-sheath nanofibres enabling staged antibiotic and peptide delivery for diabetic foot ulcer dressings. [Abstract]2026 Jul 10:700:127062. PMID: 42252032 -
Int Immunopharmacol
Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing. [Abstract]2024 Mar 30:130:111766. PMID: 38452411 -
Sci Rep
Transcriptomics changes of calcitonin gene-related peptide in mitigating lipopolysaccharide-induced septic cardiomyopathy. [Abstract]2024 Nov 2;14(1):26385. PMID: 39487252
溶剤 & 溶解度
体外:
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 16.67 mg/mL
* "≥" means soluble, but saturation unknown.
純度とドキュメンテーション
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データシート (290 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)