1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. β-Amyrenonol

β-Amyrenonol (Synonyms: 11-Oxo-β-amyrin)

Cat. No.: HY-N2920
Handling Instructions

β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.

For research use only. We do not sell to patients.

β-Amyrenonol Chemical Structure

β-Amyrenonol Chemical Structure

CAS No. : 38242-02-3

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Description

β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids[1][2].

In Vitro

β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC50 value of 26.3 µM[1].
β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells[1].
CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol[3].

Molecular Weight

440.70

Formula

C₃₀H₄₈O₂

CAS No.

38242-02-3

SMILES

C[[email protected]@]1([[email protected]@]2([H])[[email protected]@]3([[email protected]@](C(C)([[email protected]@H](O)CC3)C)([H])CC1)C)[[email protected]]4(C([[email protected]@]5([H])[[email protected]](C)(CCC(C)(C)C5)CC4)=CC2=O)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

β-Amyrenonol11-Oxo-β-amyrinCytochrome P450CYPsGlycyrrhetinicacidoleanolic-typetriterpenoidCYP88D6anti-proliferativeanti-inflammatoryTNFαInhibitorinhibitorinhibit

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