1-Naphthaleneacetic acid
Based on 1 publication(s) in Google Scholar
1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 86-87-3
- Formula: C12H10O2
- Molecular Weight:186.21
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 1-Naphthaleneacetic acid
MoreAll Phospholipase Isoforms
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Biological Activity
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PLA2 13.16 μM (IC50) |
1-Naphthaleneacetic acid (0.7-14 μM) inhibits the activity of PLA2, with the Ki and IC50 of 6.87 μM and 13.16 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86-87-3
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Appearance Solid
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Molecular Weight 186.21
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Formula C12H10O2
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Color White to off-white
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SMILES
OC(CC1=CC=CC2=C1C=CC=C2)=O
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Synonyms
1-Naphthylacetic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Plant Commun
Brassinosteroid signaling regulates PIN5/10-mediated intracellular auxin homeostasis to promote lateral root development in tomato. [Abstract]2026 Mar 16:101823. PMID: 41846312
Solvent & Solubility
Methanol : 125 mg/mL (671.29 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (537.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (555 KB)
- English - EN (555 KB)
- Français - FR (555 KB)
- Deutsch - DE (555 KB)
- Norwegian - NO (555 KB)
- Español - ES (555 KB)
- Swedish - SV (555 KB)
- Italian - IT (555 KB)
- Korean - KR (555 KB)
- Portuguese - PT (555 KB)
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Handling Instructions (2659 KB)
References
[1]. Dileep KV, et, al. Crystal structure of phospholipase A 2 in complex with 1-naphthaleneacetic acid. IUBMB Life. 2018 Oct;70(10):995-1001. [Content Brief]
[2]. Gómez DA, et al. Effect of 1-naphthaleneacetic acid on organic acid exudation by the roots of white lupin plants grown under phosphorus-deficient conditions. J Plant Physiol. 2014 Sep 15;171(15):1354-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / Methanol | 1 mM | 5.3703 mL | 26.8514 mL | 53.7028 mL | 134.2570 mL |
| 5 mM | 1.0741 mL | 5.3703 mL | 10.7406 mL | 26.8514 mL | |
| 10 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL | 13.4257 mL | |
| 15 mM | 0.3580 mL | 1.7901 mL | 3.5802 mL | 8.9505 mL | |
| 20 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 25 mM | 0.2148 mL | 1.0741 mL | 2.1481 mL | 5.3703 mL | |
| 30 mM | 0.1790 mL | 0.8950 mL | 1.7901 mL | 4.4752 mL | |
| 40 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 50 mM | 0.1074 mL | 0.5370 mL | 1.0741 mL | 2.6851 mL | |
| 60 mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 2.2376 mL | |
| 80 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 100 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3426 mL |
1-Naphthaleneacetic acid Related Classifications
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