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Cat. No.: HY-W250300

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2-(Dodecyloxy)ethanol

(Synonyms: Ethylene glycol monododecyl ether)

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2-(Dodecyloxy) ethanol (Ethylene glycol monododecyl ether) is a nonionic ether monohydroxy C₁₂ surfactant with a fragrance-like odor similar to jasmone and gardenia. 2-(Dodecyloxy) ethanol acts as a phase transition inducer and micelle-forming agent. 2-(Dodecyloxy) ethanol also serves as a skin penetration enhancer.

For research use only. We do not sell to patients.

Purity: 98.84%
CAS No.: 4536-30-5
Formula: C₁₄H₃₀O₂
Molecular Weight:230.39

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2-(Dodecyloxy)ethanol Chemical Structure

CAS No.: 4536-30-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

2-(Dodecyloxy) ethanol (0.16 M; 1 h) enhances the passive transdermal penetration of Ondansetron hydrochloride (HY-B0002) and Diltiazem hydrochloride (HY-14656) through stripped pig skin^[3].
2-(Dodecyloxy) ethanol (0.16 M; 1 h) enhances iontophoresis and post-iontophoretic transdermal penetration of ondansetron hydrochloride and diltiazem hydrochloride through stripped porcine skin^[3].
2-(Dodecyloxy) ethanol (0.016-160 μM; 24 h) is toxic to cultured human epidermal keratinocytes and reduces the viability of cultured human dermal fibroblasts to approximately 35%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

Human epidermal keratinocytes (HEK)
Concentration:

0.016-160 μM
Incubation Time:

24 h
Result:

Was lethal to all HEK at 160 μM.
Did not reduce HEK viability significantly at 16 μM.
Did not cause a significant decrease in HEK viability at concentrations of 1.6 μM or lower.

Cell Cytotoxicity Assay^[3]

Cell Line:

Human dermal fibroblasts (HDF)
Concentration:

0.016-160 μM
Incubation Time:

24 h
Result:

Reduced HDF viability to approximately 35% at 160 μM.
Did not cause a significant decrease in HDF viability at concentrations of 16 μM or lower.

Chemical Information

CAS No. 4536-30-5
Appearance Liquid (Density: 0.873 g/cm³)
Molecular Weight 230.39
Formula C₁₄H₃₀O₂
Color Colorless to light yellow
SMILES

OCCOCCCCCCCCCCCC
Synonyms

Ethylene glycol monododecyl ether
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. D’Auria M, et al. Determination of Volatile Organic Compounds in Some Epipactis, Neottia, and Limodorum Orchids Growing in Basilicata (Southern Italy). Compounds. 2024; 4(2):366-375.

[2]. Md. Nazrul Islam, et al. Temperature Dependence of the Surface Phase Behavior and Micelle Formation of Some
Nonionic Surfactants. J. Phys. Chem. B 2003, 107, 965-971.

[3]. Silva SM, et al. A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl. Eur J Pharm Biopharm. 2012;80(3):663-673. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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