1. GPCR/G Protein
  2. P2Y Receptor
  3. 2-Methylthioadenosine diphosphate trisodium

2-Methylthioadenosine diphosphate trisodium (Synonyms: 2-Methylthio-ADP trisodium)

Cat. No.: HY-108648
Handling Instructions

2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1.

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2-Methylthioadenosine diphosphate trisodium Chemical Structure

2-Methylthioadenosine diphosphate trisodium Chemical Structure

CAS No. : 475193-31-8

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Description

2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].

In Vitro

2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1].

Molecular Weight

539.24

Formula

C₁₁H₁₄N₅Na₃O₁₀P₂S

CAS No.

475193-31-8

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]](O[[email protected]@H]1CO[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)([H])N2C3=NC(SC)=NC(N)=C3N=C2

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Keywords:

2-Methylthioadenosine diphosphate trisodium2-Methylthio-ADP trisodiumP2Y ReceptorplateletaggregationshapechangecyclicAMPaccumulationsubtypesInhibitorinhibitorinhibit

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2-Methylthioadenosine diphosphate trisodium
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HY-108648
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