4,4-Diphenylbutylamine hydrochloride

Name: 4,4-Diphenylbutylamine hydrochloride
Brand: MedChemExpress
SKU: HY-141422A
Rating: 4.5 (1 reviews)

Cat. No.: HY-141422A Purity: 99.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4,4-Diphenylbutylamine shows affinity for the 5-HT_2A and H₁ receptors with K_is of 2589 and 1670 nM, respectively.

For research use only. We do not sell to patients.

4,4-Diphenylbutylamine hydrochloride Chemical Structure

CAS No. : 22101-90-2

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4,4-Diphenylbutylamine shows affinity for the 5-HT_2A and H₁ receptors with K_is of 2589 and 1670 nM, respectively^[1].

Molecular Weight

261.79

Formula

C₁₆H₂₀ClN

CAS No.

22101-90-2

Appearance

Solid

Color

White to off-white

SMILES

NCCCC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL (254.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8199 mL	19.0993 mL	38.1986 mL
5 mM	0.7640 mL	3.8199 mL	7.6397 mL
10 mM	0.3820 mL	1.9099 mL	3.8199 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.00%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (248 KB) HNMR (173 KB) RP-HPLC (155 KB) LCMS (111 KB)

Handling Instructions (2659 KB)

References

[1]. Shah JR, et al. Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009;17(18):6496-6504. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8199 mL	19.0993 mL	38.1986 mL	95.4964 mL
	5 mM	0.7640 mL	3.8199 mL	7.6397 mL	19.0993 mL
	10 mM	0.3820 mL	1.9099 mL	3.8199 mL	9.5496 mL
	15 mM	0.2547 mL	1.2733 mL	2.5466 mL	6.3664 mL
	20 mM	0.1910 mL	0.9550 mL	1.9099 mL	4.7748 mL
	25 mM	0.1528 mL	0.7640 mL	1.5279 mL	3.8199 mL
	30 mM	0.1273 mL	0.6366 mL	1.2733 mL	3.1832 mL
	40 mM	0.0955 mL	0.4775 mL	0.9550 mL	2.3874 mL
	50 mM	0.0764 mL	0.3820 mL	0.7640 mL	1.9099 mL
	60 mM	0.0637 mL	0.3183 mL	0.6366 mL	1.5916 mL
	80 mM	0.0477 mL	0.2387 mL	0.4775 mL	1.1937 mL
	100 mM	0.0382 mL	0.1910 mL	0.3820 mL	0.9550 mL