1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Brofaromine

Brofaromine (Synonyms: CGP 11305A)

Cat. No.: HY-13339 Purity: 98.55%
Handling Instructions

Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A.

For research use only. We do not sell to patients.

Brofaromine Chemical Structure

Brofaromine Chemical Structure

CAS No. : 63638-91-5

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Description

Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A.

IC50 & Target

IC50: 0.2  μM (MAO-A)[1]

In Vitro

In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01 μM to 0.1 μM[1].

Molecular Weight

310.19

Formula

C₁₄H₁₆BrNO₂

CAS No.

63638-91-5

SMILES

BrC1=CC(OC)=CC2=C1OC(C3CCNCC3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (805.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2238 mL 16.1192 mL 32.2383 mL
5 mM 0.6448 mL 3.2238 mL 6.4477 mL
10 mM 0.3224 mL 1.6119 mL 3.2238 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (20.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (20.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (20.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BrofaromineCGP 11305AMonoamine OxidaseMAOInhibitorinhibitorinhibit

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Brofaromine
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HY-13339
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